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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
23.64
Human Site:
Y517
Identified Species:
47.27
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
Y517
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
S427
K
D
S
Q
S
S
V
S
E
N
V
S
N
S
G
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
Y517
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Dog
Lupus familis
XP_547599
1258
142817
Y821
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
Y517
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Rat
Rattus norvegicus
O88763
887
101516
Y517
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
Y516
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
L396
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
M575
Q
D
E
R
A
H
D
M
Y
A
M
V
L
K
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Q616
D
P
G
Y
K
K
L
Q
M
L
V
K
K
H
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
R484
A
Q
L
C
S
I
T
R
E
V
R
N
V
R
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L512
E
S
E
D
K
P
Y
L
D
Q
I
L
S
S
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
6.6
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
20
N.A.
26.6
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
9
0
0
0
0
9
0
0
9
0
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
59
25
0
9
0
0
9
0
9
0
0
0
0
0
0
% D
% Glu:
17
0
17
0
0
50
0
0
17
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
59
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
17
% G
% His:
0
0
0
0
50
9
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% I
% Lys:
9
0
50
0
17
9
0
0
0
0
0
9
9
9
9
% K
% Leu:
0
0
17
9
0
0
17
17
50
17
0
9
9
9
0
% L
% Met:
0
0
0
0
9
0
50
9
9
0
9
50
0
0
9
% M
% Asn:
0
0
0
0
0
0
0
0
0
59
0
9
9
0
0
% N
% Pro:
0
59
0
0
0
9
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
9
0
9
0
0
0
9
9
9
0
9
0
0
0
% Q
% Arg:
0
0
0
9
0
0
0
9
0
0
9
0
50
59
0
% R
% Ser:
0
9
9
0
17
9
0
9
0
0
0
9
9
17
0
% S
% Thr:
0
0
0
50
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
9
0
0
9
75
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
9
9
50
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _