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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APPL2
All Species:
23.33
Human Site:
Y378
Identified Species:
64.17
UniProt:
Q8NEU8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEU8
NP_060641.2
664
74493
Y378
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Chimpanzee
Pan troglodytes
XP_001160746
665
74599
Y378
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538418
662
74179
Y378
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3G9
662
73835
Y378
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Rat
Rattus norvegicus
Q5FVC7
770
87211
E366
S
I
A
T
A
Y
R
E
K
G
D
E
S
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508102
695
77800
Y411
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Chicken
Gallus gallus
Q5ZK62
781
88436
G487
E
A
K
L
E
K
M
G
V
K
K
P
Q
P
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121547
662
74440
Y377
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784602
759
84098
Y382
I
R
N
I
N
S
E
Y
S
A
G
S
G
S
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
93.8
N.A.
92.4
20.2
N.A.
84.3
20.4
N.A.
69.7
N.A.
N.A.
N.A.
N.A.
33
Protein Similarity:
100
99.5
N.A.
97.2
N.A.
95.9
41.5
N.A.
89.5
40.7
N.A.
84.4
N.A.
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
13.3
N.A.
100
0
N.A.
100
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
100
20
N.A.
100
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
0
12
0
0
0
0
12
0
0
0
0
67
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
78
0
0
0
0
% D
% Glu:
12
0
0
0
12
0
12
12
0
0
0
12
0
78
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
12
0
12
12
0
12
0
12
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
12
67
12
0
0
67
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
12
0
0
12
0
0
12
12
12
0
0
0
12
% K
% Leu:
0
0
0
12
0
0
0
0
67
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% M
% Asn:
67
67
12
0
12
0
0
0
0
0
0
67
0
0
12
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
12
67
12
0
% P
% Gln:
0
0
0
0
0
67
0
0
0
0
0
0
12
0
0
% Q
% Arg:
0
12
0
0
67
0
12
0
0
0
0
0
0
0
0
% R
% Ser:
12
0
0
67
0
12
0
0
12
0
0
12
12
12
0
% S
% Thr:
0
0
0
12
0
0
0
0
0
67
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
78
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _