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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DOCK8
All Species:
9.39
Human Site:
S1243
Identified Species:
25.83
UniProt:
Q8NF50
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NF50
NP_982272.2
2099
238529
S1243
D
T
R
R
Y
R
T
S
G
S
D
E
E
Q
E
Chimpanzee
Pan troglodytes
XP_528526
2099
238441
S1243
D
T
R
R
Y
R
T
S
G
S
D
E
E
Q
E
Rhesus Macaque
Macaca mulatta
XP_001085641
2091
237677
I1221
H
N
Q
R
G
R
P
I
C
I
A
T
D
D
Y
Dog
Lupus familis
XP_533535
2033
231227
S1186
D
E
E
Q
E
G
T
S
A
I
N
Q
N
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8C147
2100
238960
S1244
R
S
G
R
S
R
A
S
G
S
Y
E
E
Q
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_424926
2034
231292
A1188
E
E
Q
E
S
A
G
A
I
S
Q
N
V
A
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001920107
2136
242821
K1278
D
S
R
S
G
K
G
K
S
G
G
P
E
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608489
2064
234687
L1264
N
E
Q
V
K
N
K
L
P
L
S
S
E
N
T
Honey Bee
Apis mellifera
XP_394718
1977
220817
H1200
L
S
S
E
A
T
R
H
L
L
M
C
V
L
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
57.1
90.9
N.A.
91.9
N.A.
N.A.
N.A.
79.6
N.A.
65.8
N.A.
43.6
42.6
N.A.
N.A.
Protein Similarity:
100
99.7
74.8
94
N.A.
95.7
N.A.
N.A.
N.A.
87.8
N.A.
80.2
N.A.
63.4
61.7
N.A.
N.A.
P-Site Identity:
100
100
13.3
20
N.A.
53.3
N.A.
N.A.
N.A.
6.6
N.A.
20
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
100
26.6
40
N.A.
66.6
N.A.
N.A.
N.A.
26.6
N.A.
46.6
N.A.
20
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
12
12
12
12
0
12
0
0
12
12
% A
% Cys:
0
0
0
0
0
0
0
0
12
0
0
12
0
0
0
% C
% Asp:
45
0
0
0
0
0
0
0
0
0
23
0
12
12
23
% D
% Glu:
12
34
12
23
12
0
0
0
0
0
0
34
56
12
23
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
12
0
23
12
23
0
34
12
12
0
0
0
0
% G
% His:
12
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
12
12
23
0
0
0
0
0
% I
% Lys:
0
0
0
0
12
12
12
12
0
0
0
0
0
0
0
% K
% Leu:
12
0
0
0
0
0
0
12
12
23
0
0
0
12
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
12
12
0
0
0
12
0
0
0
0
12
12
12
12
0
% N
% Pro:
0
0
0
0
0
0
12
0
12
0
0
12
0
0
0
% P
% Gln:
0
0
34
12
0
0
0
0
0
0
12
12
0
34
0
% Q
% Arg:
12
0
34
45
0
45
12
0
0
0
0
0
0
0
0
% R
% Ser:
0
34
12
12
23
0
0
45
12
45
12
12
0
0
0
% S
% Thr:
0
23
0
0
0
12
34
0
0
0
0
12
0
0
12
% T
% Val:
0
0
0
12
0
0
0
0
0
0
0
0
23
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% W
% Tyr:
0
0
0
0
23
0
0
0
0
0
12
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _