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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FLCN
All Species:
28.48
Human Site:
S246
Identified Species:
52.22
UniProt:
Q8NFG4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NFG4
NP_653207.1
579
64473
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Chimpanzee
Pan troglodytes
XP_001160873
582
64513
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Rhesus Macaque
Macaca mulatta
XP_001088928
579
64261
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZS3
579
64309
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Rat
Rattus norvegicus
Q76JQ2
579
64103
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510766
579
64602
S246
R
S
L
T
S
L
T
S
D
E
N
L
W
A
C
Chicken
Gallus gallus
XP_414807
579
64831
N246
R
S
L
T
S
L
T
N
D
E
N
L
W
A
C
Frog
Xenopus laevis
NP_001121308
579
64849
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Zebra Danio
Brachydanio rerio
NP_001035463
558
62158
A226
P
H
Q
R
S
G
N
A
A
R
S
L
T
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648090
460
51900
K142
I
I
V
L
M
K
D
K
Y
F
L
L
N
I
K
Honey Bee
Apis mellifera
XP_624515
471
53289
K153
E
L
Q
D
F
A
E
K
K
Y
N
A
E
E
A
Nematode Worm
Caenorhab. elegans
NP_001022107
635
71518
E314
E
D
D
I
H
K
P
E
F
Q
K
L
V
G
K
Sea Urchin
Strong. purpuratus
XP_790040
519
58408
S200
S
L
I
D
E
L
K
S
K
S
N
K
V
Y
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95
98.7
N.A.
N.A.
92.5
92.7
N.A.
92.2
87.9
82.2
62.1
N.A.
25.7
28.6
22.2
41.9
Protein Similarity:
100
95.6
98.9
N.A.
N.A.
94.8
94.8
N.A.
96.1
93.4
89.2
73.4
N.A.
43.1
46.9
39.2
59
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
86.6
100
13.3
N.A.
6.6
6.6
6.6
20
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
100
33.3
N.A.
13.3
6.6
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
8
8
0
0
8
0
62
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
62
% C
% Asp:
0
8
8
16
0
0
8
0
62
47
0
0
0
0
0
% D
% Glu:
16
0
0
0
8
0
8
8
0
16
0
0
8
8
8
% E
% Phe:
0
0
0
0
8
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% G
% His:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
8
8
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
16
8
16
16
0
8
8
0
0
16
% K
% Leu:
0
16
62
8
0
70
0
0
0
0
8
85
0
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
77
0
8
0
0
% N
% Pro:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
62
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
8
62
0
0
70
0
0
62
0
8
8
0
0
8
0
% S
% Thr:
0
0
0
62
0
0
62
0
0
0
0
0
8
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
62
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _