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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FLCN
All Species:
23.03
Human Site:
S298
Identified Species:
42.22
UniProt:
Q8NFG4
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NFG4
NP_653207.1
579
64473
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Chimpanzee
Pan troglodytes
XP_001160873
582
64513
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Rhesus Macaque
Macaca mulatta
XP_001088928
579
64261
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZS3
579
64309
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Rat
Rattus norvegicus
Q76JQ2
579
64103
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510766
579
64602
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
G
E
Chicken
Gallus gallus
XP_414807
579
64831
G298
D
L
R
E
E
S
E
G
W
D
G
S
E
E
E
Frog
Xenopus laevis
NP_001121308
579
64849
A298
D
L
E
E
E
C
A
A
R
E
G
A
D
G
E
Zebra Danio
Brachydanio rerio
NP_001035463
558
62158
Q278
T
L
V
L
I
E
R
Q
T
E
Q
E
E
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648090
460
51900
T194
G
A
Q
F
L
M
P
T
S
R
A
L
L
E
L
Honey Bee
Apis mellifera
XP_624515
471
53289
L205
F
I
R
I
H
M
W
L
V
W
I
L
S
A
G
Nematode Worm
Caenorhab. elegans
NP_001022107
635
71518
C366
L
R
S
P
T
L
A
C
L
D
Q
V
M
E
G
Sea Urchin
Strong. purpuratus
XP_790040
519
58408
F252
L
T
G
D
A
N
L
F
K
Y
L
H
M
R
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95
98.7
N.A.
N.A.
92.5
92.7
N.A.
92.2
87.9
82.2
62.1
N.A.
25.7
28.6
22.2
41.9
Protein Similarity:
100
95.6
98.9
N.A.
N.A.
94.8
94.8
N.A.
96.1
93.4
89.2
73.4
N.A.
43.1
46.9
39.2
59
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
73.3
40
13.3
N.A.
0
6.6
6.6
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
73.3
66.6
20
N.A.
13.3
13.3
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
16
8
0
0
8
8
0
47
0
% A
% Cys:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% C
% Asp:
62
0
0
8
0
0
0
0
0
62
0
0
8
0
0
% D
% Glu:
0
0
54
62
62
8
54
0
0
16
0
8
62
31
62
% E
% Phe:
8
0
0
8
0
0
0
8
0
0
0
0
0
0
8
% F
% Gly:
8
0
8
0
0
0
0
8
0
0
16
0
0
16
16
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
8
0
8
8
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
16
70
0
8
8
8
8
8
8
0
8
16
8
0
8
% L
% Met:
0
0
0
0
0
16
0
0
0
0
0
0
16
0
8
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
47
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
8
0
0
16
0
0
0
0
% Q
% Arg:
0
8
16
0
0
0
8
0
8
8
0
0
0
8
0
% R
% Ser:
0
0
8
0
0
54
0
47
8
0
0
54
8
0
0
% S
% Thr:
8
8
0
0
8
0
0
8
8
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
8
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
54
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _