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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FLCN All Species: 26.67
Human Site: Y95 Identified Species: 48.89
UniProt: Q8NFG4 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NFG4 NP_653207.1 579 64473 Y95 L A A G H P G Y I S H D K E T
Chimpanzee Pan troglodytes XP_001160873 582 64513 Y95 L A A G H P G Y I S H D K E T
Rhesus Macaque Macaca mulatta XP_001088928 579 64261 Y95 L A A G H P G Y I S H D K E T
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8QZS3 579 64309 Y95 L A V G H P G Y I S H D K E T
Rat Rattus norvegicus Q76JQ2 579 64103 Y95 L A V G H P G Y I S H D K E T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510766 579 64602 Y95 L A A G H P G Y I S H D K E T
Chicken Gallus gallus XP_414807 579 64831 F95 L A G G H P G F V S H D K E T
Frog Xenopus laevis NP_001121308 579 64849 Y95 L A A G H P G Y I S H D K E T
Zebra Danio Brachydanio rerio NP_001035463 558 62158 F82 L P A S H P G F V S V D G E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648090 460 51900 Q23 P C A I F C T Q T L R D T K L
Honey Bee Apis mellifera XP_624515 471 53289 C34 G Q Y E C E G C Q S I G N V K
Nematode Worm Caenorhab. elegans NP_001022107 635 71518 L106 S F R N G P C L L S N D H Q T
Sea Urchin Strong. purpuratus XP_790040 519 58408 E81 A S S T E H C E A C R S F Q P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95 98.7 N.A. N.A. 92.5 92.7 N.A. 92.2 87.9 82.2 62.1 N.A. 25.7 28.6 22.2 41.9
Protein Similarity: 100 95.6 98.9 N.A. N.A. 94.8 94.8 N.A. 96.1 93.4 89.2 73.4 N.A. 43.1 46.9 39.2 59
P-Site Identity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 100 80 100 60 N.A. 13.3 13.3 26.6 0
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 100 93.3 100 73.3 N.A. 20 13.3 46.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 62 54 0 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 8 0 0 8 8 16 8 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 85 0 0 0 % D
% Glu: 0 0 0 8 8 8 0 8 0 0 0 0 0 70 0 % E
% Phe: 0 8 0 0 8 0 0 16 0 0 0 0 8 0 0 % F
% Gly: 8 0 8 62 8 0 77 0 0 0 0 8 8 0 0 % G
% His: 0 0 0 0 70 8 0 0 0 0 62 0 8 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 54 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 62 8 8 % K
% Leu: 70 0 0 0 0 0 0 8 8 8 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 8 0 8 0 0 % N
% Pro: 8 8 0 0 0 77 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 8 0 0 0 0 0 8 8 0 0 0 0 16 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 0 16 0 0 0 0 % R
% Ser: 8 8 8 8 0 0 0 0 0 85 0 8 0 0 0 % S
% Thr: 0 0 0 8 0 0 8 0 8 0 0 0 8 0 77 % T
% Val: 0 0 16 0 0 0 0 0 16 0 8 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 54 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _