KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADCY4
All Species:
17.27
Human Site:
T459
Identified Species:
34.55
UniProt:
Q8NFM4
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NFM4
NP_640340.2
1077
119794
T459
E
E
E
D
E
K
G
T
A
G
G
L
L
S
S
Chimpanzee
Pan troglodytes
XP_509874
1077
119824
T459
E
E
E
D
E
K
G
T
A
G
G
L
L
S
S
Rhesus Macaque
Macaca mulatta
XP_001104563
1022
113895
M429
Y
A
V
E
D
A
G
M
E
H
R
D
P
Y
L
Dog
Lupus familis
XP_537394
1077
119478
T459
E
E
E
D
E
K
G
T
A
G
G
L
L
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q91WF3
1077
120361
T459
E
E
E
D
E
K
G
T
A
K
G
L
L
S
S
Rat
Rattus norvegicus
P26770
1064
118781
T459
E
E
E
D
E
K
G
T
E
R
G
L
L
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519046
1069
121143
H454
G
E
R
R
S
P
Q
H
L
F
R
P
R
H
T
Chicken
Gallus gallus
Q9DGG6
1334
149273
D628
P
P
C
D
V
S
I
D
E
G
A
I
Q
N
G
Frog
Xenopus laevis
P98999
1305
145393
V638
R
D
G
P
E
E
G
V
S
A
A
N
G
G
G
Zebra Danio
Brachydanio rerio
NP_001093457
1139
128958
L522
A
E
K
R
S
P
L
L
L
S
A
I
R
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VW60
1307
142798
Q700
S
R
R
K
L
S
V
Q
G
L
M
S
F
A
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780688
889
100312
F315
W
S
G
A
D
K
P
F
Q
Q
I
A
T
M
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
93.7
94.3
N.A.
92.3
91.2
N.A.
54.7
27.4
28.9
52.7
N.A.
34.4
N.A.
N.A.
37.2
Protein Similarity:
100
99.9
94
96.4
N.A.
94.3
93.3
N.A.
69.7
42.4
44.6
68.3
N.A.
49.5
N.A.
N.A.
53
P-Site Identity:
100
100
6.6
100
N.A.
93.3
86.6
N.A.
6.6
13.3
13.3
6.6
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
20
100
N.A.
93.3
86.6
N.A.
13.3
26.6
33.3
26.6
N.A.
6.6
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
0
9
0
0
34
9
25
9
0
9
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
50
17
0
0
9
0
0
0
9
0
0
9
% D
% Glu:
42
59
42
9
50
9
0
0
25
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
9
0
0
9
0
0
% F
% Gly:
9
0
17
0
0
0
59
0
9
34
42
0
9
9
17
% G
% His:
0
0
0
0
0
0
0
9
0
9
0
0
0
9
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
9
17
0
0
0
% I
% Lys:
0
0
9
9
0
50
0
0
0
9
0
0
0
0
0
% K
% Leu:
0
0
0
0
9
0
9
9
17
9
0
42
42
0
9
% L
% Met:
0
0
0
0
0
0
0
9
0
0
9
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
0
9
0
% N
% Pro:
9
9
0
9
0
17
9
0
0
0
0
9
9
9
9
% P
% Gln:
0
0
0
0
0
0
9
9
9
9
0
0
9
0
0
% Q
% Arg:
9
9
17
17
0
0
0
0
0
9
17
0
17
0
0
% R
% Ser:
9
9
0
0
17
17
0
0
9
9
0
9
0
42
42
% S
% Thr:
0
0
0
0
0
0
0
42
0
0
0
0
9
0
17
% T
% Val:
0
0
9
0
9
0
9
9
0
0
0
0
0
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _