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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELB
All Species:
17.88
Human Site:
S643
Identified Species:
65.56
UniProt:
Q8NG08
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NG08
NP_387467.2
1087
123252
S643
D
L
F
E
T
L
K
S
R
N
C
A
I
E
L
Chimpanzee
Pan troglodytes
XP_001162205
1087
123069
S643
D
L
F
E
T
L
K
S
R
N
C
A
I
E
L
Rhesus Macaque
Macaca mulatta
XP_001117092
1087
123384
S643
D
L
F
E
T
L
K
S
R
N
C
A
I
E
L
Dog
Lupus familis
XP_850757
1135
127179
S689
D
L
F
E
T
L
K
S
R
N
C
A
I
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6NVF4
1074
121465
S623
D
V
F
E
T
L
K
S
R
Q
C
A
I
E
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510881
1045
117531
G612
Q
L
P
S
I
E
P
G
N
L
L
M
D
M
F
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001336777
973
109393
R540
S
A
V
P
S
D
K
R
F
I
F
I
K
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
94.9
67.6
N.A.
62.4
N.A.
N.A.
50.8
N.A.
N.A.
33.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
97
77.6
N.A.
74.1
N.A.
N.A.
66.1
N.A.
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
N.A.
N.A.
6.6
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
N.A.
N.A.
6.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
0
0
0
0
0
0
0
0
72
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
0
% C
% Asp:
72
0
0
0
0
15
0
0
0
0
0
0
15
0
0
% D
% Glu:
0
0
0
72
0
15
0
0
0
0
0
0
0
72
0
% E
% Phe:
0
0
72
0
0
0
0
0
15
0
15
0
0
0
15
% F
% Gly:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
15
0
0
0
0
15
0
15
72
15
0
% I
% Lys:
0
0
0
0
0
0
86
0
0
0
0
0
15
0
0
% K
% Leu:
0
72
0
0
0
72
0
0
0
15
15
0
0
0
72
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
15
0
15
0
% M
% Asn:
0
0
0
0
0
0
0
0
15
58
0
0
0
0
0
% N
% Pro:
0
0
15
15
0
0
15
0
0
0
0
0
0
0
0
% P
% Gln:
15
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
15
72
0
0
0
0
0
0
% R
% Ser:
15
0
0
15
15
0
0
72
0
0
0
0
0
0
15
% S
% Thr:
0
0
0
0
72
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
15
15
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _