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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTL
All Species:
7.58
Human Site:
T369
Identified Species:
20.83
UniProt:
Q8NG68
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NG68
NP_714923.1
377
43212
T369
P
D
V
E
Q
P
Q
T
Q
P
A
A
F
I
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087668
377
43168
T369
P
D
V
E
Q
P
Q
T
Q
P
A
A
F
T
K
Dog
Lupus familis
XP_540180
377
43336
I369
P
D
V
E
P
Q
H
I
Q
P
A
A
F
I
K
Cat
Felis silvestris
Mouse
Mus musculus
P38585
377
43118
Q369
P
D
T
E
Q
V
P
Q
Q
P
A
A
F
V
K
Rat
Rattus norvegicus
Q9QXJ0
377
43100
Q369
P
D
T
E
Q
V
P
Q
Q
P
A
A
F
M
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518878
138
16145
N131
K
V
W
L
I
E
V
N
G
A
P
A
C
A
Q
Chicken
Gallus gallus
XP_415008
378
43477
S369
A
D
T
G
Q
K
T
S
Q
P
T
S
I
F
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070093
307
35280
T300
H
I
I
R
C
S
F
T
K
K
S
L
F
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787911
386
43119
H376
E
H
V
E
T
E
I
H
G
A
S
C
R
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.4
95.2
N.A.
95.2
94.6
N.A.
32.6
88.6
N.A.
63.1
N.A.
N.A.
N.A.
N.A.
48.9
Protein Similarity:
100
N.A.
99.7
97.8
N.A.
97.8
97.6
N.A.
35
93.6
N.A.
71.8
N.A.
N.A.
N.A.
N.A.
65.8
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
66.6
66.6
N.A.
6.6
26.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
93.3
73.3
N.A.
73.3
73.3
N.A.
13.3
40
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
0
0
0
23
56
67
0
12
0
% A
% Cys:
0
0
0
0
12
0
0
0
0
0
0
12
12
0
0
% C
% Asp:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
12
0
0
67
0
23
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
12
0
0
0
0
0
67
12
12
% F
% Gly:
0
0
0
12
0
0
0
0
23
0
0
0
0
0
0
% G
% His:
12
12
0
0
0
0
12
12
0
0
0
0
0
0
0
% H
% Ile:
0
12
12
0
12
0
12
12
0
0
0
0
12
23
12
% I
% Lys:
12
0
0
0
0
12
0
0
12
12
0
0
0
0
56
% K
% Leu:
0
0
0
12
0
0
0
0
0
0
0
12
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% M
% Asn:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% N
% Pro:
56
0
0
0
12
23
23
0
0
67
12
0
0
0
12
% P
% Gln:
0
0
0
0
56
12
23
23
67
0
0
0
0
0
12
% Q
% Arg:
0
0
0
12
0
0
0
0
0
0
0
0
12
0
0
% R
% Ser:
0
0
0
0
0
12
0
12
0
0
23
12
0
12
0
% S
% Thr:
0
0
34
0
12
0
12
34
0
0
12
0
0
12
0
% T
% Val:
0
12
45
0
0
23
12
0
0
0
0
0
0
23
0
% V
% Trp:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _