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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTL
All Species:
22.42
Human Site:
Y216
Identified Species:
61.67
UniProt:
Q8NG68
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NG68
NP_714923.1
377
43212
Y216
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087668
377
43168
Y216
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Dog
Lupus familis
XP_540180
377
43336
Y216
H
Q
Y
N
I
Y
L
Y
K
E
G
V
L
R
T
Cat
Felis silvestris
Mouse
Mus musculus
P38585
377
43118
Y216
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Rat
Rattus norvegicus
Q9QXJ0
377
43100
Y216
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518878
138
16145
Chicken
Gallus gallus
XP_415008
378
43477
Y216
H
L
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070093
307
35280
I164
A
G
A
K
G
A
G
I
L
I
S
H
D
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787911
386
43119
M223
H
Q
Y
N
I
Y
L
M
K
E
G
V
L
R
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.4
95.2
N.A.
95.2
94.6
N.A.
32.6
88.6
N.A.
63.1
N.A.
N.A.
N.A.
N.A.
48.9
Protein Similarity:
100
N.A.
99.7
97.8
N.A.
97.8
97.6
N.A.
35
93.6
N.A.
71.8
N.A.
N.A.
N.A.
N.A.
65.8
P-Site Identity:
100
N.A.
100
93.3
N.A.
100
100
N.A.
0
93.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
86.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
93.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
12
0
0
12
0
0
0
0
0
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
78
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
12
0
12
0
0
0
78
0
0
0
0
% G
% His:
78
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% H
% Ile:
0
0
0
0
78
0
0
12
0
12
0
0
0
0
0
% I
% Lys:
0
0
0
12
0
0
0
0
23
0
0
0
0
0
0
% K
% Leu:
0
12
0
0
0
0
78
0
12
0
0
0
78
0
0
% L
% Met:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
78
0
0
0
0
0
0
0
0
0
0
12
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
56
0
0
0
0
78
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
78
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
78
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
78
0
0
78
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _