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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTL
All Species:
23.33
Human Site:
Y256
Identified Species:
64.17
UniProt:
Q8NG68
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NG68
NP_714923.1
377
43212
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087668
377
43168
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Dog
Lupus familis
XP_540180
377
43336
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Cat
Felis silvestris
Mouse
Mus musculus
P38585
377
43118
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Rat
Rattus norvegicus
Q9QXJ0
377
43100
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518878
138
16145
T35
I
T
N
F
Q
D
Q
T
C
H
L
T
N
H
C
Chicken
Gallus gallus
XP_415008
378
43477
Y256
Y
S
K
N
Y
G
R
Y
E
E
G
N
E
M
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070093
307
35280
D204
E
P
G
H
R
K
F
D
I
R
S
W
V
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787911
386
43119
F263
H
S
K
D
F
G
K
F
E
E
G
N
E
M
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.4
95.2
N.A.
95.2
94.6
N.A.
32.6
88.6
N.A.
63.1
N.A.
N.A.
N.A.
N.A.
48.9
Protein Similarity:
100
N.A.
99.7
97.8
N.A.
97.8
97.6
N.A.
35
93.6
N.A.
71.8
N.A.
N.A.
N.A.
N.A.
65.8
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
93.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
73.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
13.3
100
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
12
% C
% Asp:
0
0
0
12
0
12
0
12
0
0
0
0
0
0
0
% D
% Glu:
12
0
0
0
0
0
0
0
78
78
0
0
78
0
0
% E
% Phe:
0
0
0
12
12
0
12
12
0
0
0
0
0
0
78
% F
% Gly:
0
0
12
0
0
78
0
0
0
0
78
0
0
0
0
% G
% His:
12
0
0
12
0
0
0
0
0
12
0
0
0
12
0
% H
% Ile:
12
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% I
% Lys:
0
0
78
0
0
12
67
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
12
0
0
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
78
0
% M
% Asn:
0
0
12
67
0
0
0
0
0
0
0
78
12
0
0
% N
% Pro:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
12
0
12
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
12
0
12
0
0
12
0
0
0
0
0
% R
% Ser:
0
78
0
0
0
0
0
0
0
0
12
0
0
0
0
% S
% Thr:
0
12
0
0
0
0
0
12
0
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% W
% Tyr:
67
0
0
0
67
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _