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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNRF2
All Species:
1.52
Human Site:
S106
Identified Species:
2.78
UniProt:
Q8NHG8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NHG8
NP_667339.1
242
24115
S106
S
P
F
S
I
P
N
S
S
S
G
P
Y
G
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001109563
278
29893
G142
R
W
F
S
S
H
S
G
F
K
C
P
I
C
S
Dog
Lupus familis
XP_854366
187
20677
N55
Q
W
E
Q
S
N
S
N
D
Y
S
S
L
Y
L
Cat
Felis silvestris
Mouse
Mus musculus
Q71FD5
238
23687
G102
I
P
S
A
G
G
G
G
G
P
Y
G
S
Q
D
Rat
Rattus norvegicus
NP_001102098
245
24500
G109
P
S
S
G
G
G
S
G
G
P
Y
G
S
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512110
89
10164
Chicken
Gallus gallus
XP_418778
146
15603
G13
F
N
I
P
H
S
S
G
P
Y
G
S
Q
D
S
Frog
Xenopus laevis
Q66KG7
195
20714
G63
P
A
A
A
L
P
F
G
L
Y
R
A
G
P
D
Zebra Danio
Brachydanio rerio
Q08CN9
217
22620
I84
R
P
Q
S
G
I
N
I
P
N
S
G
A
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572359
303
31946
R167
M
Q
S
Y
M
Q
Q
R
R
T
L
G
D
S
I
Honey Bee
Apis mellifera
XP_624991
212
22738
E79
V
P
D
L
T
S
G
E
Q
S
S
L
A
S
S
Nematode Worm
Caenorhab. elegans
NP_491059
189
21030
S57
A
R
F
L
S
S
S
S
D
S
N
A
S
E
D
Sea Urchin
Strong. purpuratus
XP_001198564
213
21441
G81
G
Q
A
M
N
I
P
G
G
S
G
A
S
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
34.1
55.7
N.A.
85.1
76.3
N.A.
35.9
53.3
43.3
67.7
N.A.
39.5
41.7
35.9
41.7
Protein Similarity:
100
N.A.
43.5
60.7
N.A.
86.7
79.5
N.A.
35.9
54.9
53.3
75.2
N.A.
49.5
53.3
48.7
54.9
P-Site Identity:
100
N.A.
26.6
0
N.A.
6.6
0
N.A.
0
13.3
6.6
26.6
N.A.
0
20
20
13.3
P-Site Similarity:
100
N.A.
33.3
13.3
N.A.
13.3
6.6
N.A.
0
20
20
33.3
N.A.
13.3
20
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
16
0
0
0
0
0
0
0
24
16
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% C
% Asp:
0
0
8
0
0
0
0
0
16
0
0
0
8
8
31
% D
% Glu:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% E
% Phe:
8
0
24
0
0
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
24
16
16
47
24
0
24
31
8
8
8
% G
% His:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
0
8
16
0
8
0
0
0
0
8
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
0
0
16
8
0
0
0
8
0
8
8
8
0
8
% L
% Met:
8
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
8
8
16
8
0
8
8
0
0
0
0
% N
% Pro:
16
31
0
8
0
16
8
0
16
16
0
16
0
8
0
% P
% Gln:
8
16
8
8
0
8
8
0
8
0
0
0
8
16
0
% Q
% Arg:
16
8
0
0
0
0
0
8
8
0
8
0
0
8
0
% R
% Ser:
8
8
24
24
24
24
39
16
8
31
24
16
31
16
39
% S
% Thr:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
24
16
0
8
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _