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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNRF2
All Species:
10.3
Human Site:
S145
Identified Species:
18.89
UniProt:
Q8NHG8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NHG8
NP_667339.1
242
24115
S145
G
P
R
L
V
I
G
S
L
P
A
H
L
S
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001109563
278
29893
R181
G
R
I
Q
R
S
L
R
G
A
Q
P
E
K
T
Dog
Lupus familis
XP_854366
187
20677
K94
W
F
L
Q
A
M
L
K
W
I
S
F
T
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q71FD5
238
23687
S141
G
P
R
L
V
I
G
S
L
P
A
H
L
S
P
Rat
Rattus norvegicus
NP_001102098
245
24500
S148
G
P
R
L
V
I
G
S
L
P
A
H
L
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512110
89
10164
Chicken
Gallus gallus
XP_418778
146
15603
A52
L
V
I
G
S
L
P
A
H
L
S
P
H
L
F
Frog
Xenopus laevis
Q66KG7
195
20714
P102
A
D
T
L
H
I
T
P
R
W
I
G
A
H
S
Zebra Danio
Brachydanio rerio
Q08CN9
217
22620
A123
L
V
I
G
S
L
P
A
H
L
S
P
H
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572359
303
31946
A206
G
I
G
R
V
Y
T
A
T
S
L
P
S
H
I
Honey Bee
Apis mellifera
XP_624991
212
22738
L118
R
V
Y
A
A
H
S
L
P
S
H
I
W
S
L
Nematode Worm
Caenorhab. elegans
NP_491059
189
21030
S96
H
G
H
H
S
R
R
S
V
P
V
F
M
M
D
Sea Urchin
Strong. purpuratus
XP_001198564
213
21441
G120
S
S
T
S
G
A
S
G
S
G
G
G
G
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
34.1
55.7
N.A.
85.1
76.3
N.A.
35.9
53.3
43.3
67.7
N.A.
39.5
41.7
35.9
41.7
Protein Similarity:
100
N.A.
43.5
60.7
N.A.
86.7
79.5
N.A.
35.9
54.9
53.3
75.2
N.A.
49.5
53.3
48.7
54.9
P-Site Identity:
100
N.A.
6.6
0
N.A.
100
100
N.A.
0
0
13.3
0
N.A.
13.3
6.6
13.3
0
P-Site Similarity:
100
N.A.
6.6
13.3
N.A.
100
100
N.A.
0
20
13.3
20
N.A.
20
6.6
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
16
8
0
24
0
8
24
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
16
0
8
16
% F
% Gly:
39
8
8
16
8
0
24
8
8
8
8
16
8
8
0
% G
% His:
8
0
8
8
8
8
0
0
16
0
8
24
16
16
0
% H
% Ile:
0
8
24
0
0
31
0
0
0
8
8
8
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% K
% Leu:
16
0
8
31
0
16
16
8
24
16
8
0
24
16
16
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
24
0
0
0
0
16
8
8
31
0
31
0
0
24
% P
% Gln:
0
0
0
16
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
8
8
24
8
8
8
8
8
8
0
0
0
0
0
8
% R
% Ser:
8
8
0
8
24
8
16
31
8
16
24
0
8
31
8
% S
% Thr:
0
0
16
0
0
0
16
0
8
0
0
0
8
0
8
% T
% Val:
0
24
0
0
31
0
0
0
8
0
8
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
8
8
0
0
8
0
0
% W
% Tyr:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _