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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNRF2
All Species:
1.21
Human Site:
S28
Identified Species:
2.22
UniProt:
Q8NHG8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NHG8
NP_667339.1
242
24115
S28
S
D
L
P
S
S
S
S
G
G
A
N
G
T
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001109563
278
29893
P28
D
D
S
A
V
P
P
P
G
G
A
P
H
F
G
Dog
Lupus familis
XP_854366
187
20677
Cat
Felis silvestris
Mouse
Mus musculus
Q71FD5
238
23687
S28
D
L
P
S
G
T
G
S
G
G
G
G
A
D
G
Rat
Rattus norvegicus
NP_001102098
245
24500
G28
D
L
P
S
G
T
S
G
G
G
G
A
D
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512110
89
10164
Chicken
Gallus gallus
XP_418778
146
15603
Frog
Xenopus laevis
Q66KG7
195
20714
Zebra Danio
Brachydanio rerio
Q08CN9
217
22620
R15
P
A
A
N
G
R
T
R
A
Y
S
G
S
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572359
303
31946
N42
Q
Q
Q
H
Q
H
S
N
P
G
Q
N
R
G
G
Honey Bee
Apis mellifera
XP_624991
212
22738
Q10
A
K
A
S
T
V
A
Q
S
A
G
D
N
G
Q
Nematode Worm
Caenorhab. elegans
NP_491059
189
21030
Sea Urchin
Strong. purpuratus
XP_001198564
213
21441
V12
V
S
S
S
P
R
T
V
Y
G
A
G
V
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
34.1
55.7
N.A.
85.1
76.3
N.A.
35.9
53.3
43.3
67.7
N.A.
39.5
41.7
35.9
41.7
Protein Similarity:
100
N.A.
43.5
60.7
N.A.
86.7
79.5
N.A.
35.9
54.9
53.3
75.2
N.A.
49.5
53.3
48.7
54.9
P-Site Identity:
100
N.A.
26.6
0
N.A.
20
26.6
N.A.
0
0
0
0
N.A.
20
0
0
13.3
P-Site Similarity:
100
N.A.
26.6
0
N.A.
26.6
33.3
N.A.
0
0
0
13.3
N.A.
26.6
26.6
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
8
0
0
8
0
8
8
24
8
8
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
24
16
0
0
0
0
0
0
0
0
0
8
8
16
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
24
0
8
8
31
47
24
24
8
31
31
% G
% His:
0
0
0
8
0
8
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
16
8
0
0
0
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
0
16
8
0
0
% N
% Pro:
8
0
16
8
8
8
8
8
8
0
0
8
0
0
0
% P
% Gln:
8
8
8
0
8
0
0
8
0
0
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
16
0
8
0
0
0
0
8
0
0
% R
% Ser:
8
8
16
31
8
8
24
16
8
0
8
0
8
0
0
% S
% Thr:
0
0
0
0
8
16
16
0
0
0
0
0
0
8
0
% T
% Val:
8
0
0
0
8
8
0
8
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _