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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNRF2
All Species:
2.42
Human Site:
Y111
Identified Species:
4.44
UniProt:
Q8NHG8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NHG8
NP_667339.1
242
24115
Y111
P
N
S
S
S
G
P
Y
G
S
Q
D
S
V
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001109563
278
29893
I147
H
S
G
F
K
C
P
I
C
S
K
S
V
A
S
Dog
Lupus familis
XP_854366
187
20677
L60
N
S
N
D
Y
S
S
L
Y
L
Y
L
F
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q71FD5
238
23687
S107
G
G
G
G
P
Y
G
S
Q
D
S
V
H
S
S
Rat
Rattus norvegicus
NP_001102098
245
24500
S114
G
S
G
G
P
Y
G
S
Q
D
S
V
H
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512110
89
10164
Chicken
Gallus gallus
XP_418778
146
15603
Q18
S
S
G
P
Y
G
S
Q
D
S
V
S
S
T
P
Frog
Xenopus laevis
Q66KG7
195
20714
G68
P
F
G
L
Y
R
A
G
P
D
T
E
R
G
G
Zebra Danio
Brachydanio rerio
Q08CN9
217
22620
A89
I
N
I
P
N
S
G
A
Y
S
S
A
D
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572359
303
31946
D172
Q
Q
R
R
T
L
G
D
S
I
R
D
M
S
M
Honey Bee
Apis mellifera
XP_624991
212
22738
A84
S
G
E
Q
S
S
L
A
S
S
V
G
V
G
V
Nematode Worm
Caenorhab. elegans
NP_491059
189
21030
S62
S
S
S
D
S
N
A
S
E
D
D
A
G
P
S
Sea Urchin
Strong. purpuratus
XP_001198564
213
21441
S86
I
P
G
G
S
G
A
S
R
G
P
D
S
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
34.1
55.7
N.A.
85.1
76.3
N.A.
35.9
53.3
43.3
67.7
N.A.
39.5
41.7
35.9
41.7
Protein Similarity:
100
N.A.
43.5
60.7
N.A.
86.7
79.5
N.A.
35.9
54.9
53.3
75.2
N.A.
49.5
53.3
48.7
54.9
P-Site Identity:
100
N.A.
13.3
0
N.A.
0
0
N.A.
0
20
6.6
13.3
N.A.
6.6
13.3
13.3
26.6
P-Site Similarity:
100
N.A.
26.6
13.3
N.A.
0
6.6
N.A.
0
26.6
13.3
20
N.A.
20
13.3
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
24
16
0
0
0
16
0
8
0
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
0
8
8
31
8
24
8
16
0
% D
% Glu:
0
0
8
0
0
0
0
0
8
0
0
8
0
0
0
% E
% Phe:
0
8
0
8
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
16
16
47
24
0
24
31
8
8
8
0
8
8
16
16
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
16
0
8
% H
% Ile:
16
0
8
0
0
0
0
8
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
0
8
0
8
8
8
0
8
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
8
16
8
0
8
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
16
8
0
16
16
0
16
0
8
0
8
0
0
8
16
% P
% Gln:
8
8
0
8
0
0
0
8
16
0
8
0
0
0
8
% Q
% Arg:
0
0
8
8
0
8
0
0
8
0
8
0
8
0
0
% R
% Ser:
24
39
16
8
31
24
16
31
16
39
24
16
24
31
31
% S
% Thr:
0
0
0
0
8
0
0
0
0
0
8
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
16
16
16
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
24
16
0
8
16
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _