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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RFWD2
All Species:
29.09
Human Site:
Y583
Identified Species:
53.33
UniProt:
Q8NHY2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NHY2
NP_001001740.1
731
80474
Y583
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Chimpanzee
Pan troglodytes
XP_001153038
711
78047
Y563
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Rhesus Macaque
Macaca mulatta
XP_001104796
731
80323
Y583
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Dog
Lupus familis
XP_537181
733
80411
Y585
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1A8
733
80423
Y585
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Rat
Rattus norvegicus
NP_001020297
433
48631
D286
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515470
711
80322
Y552
E
N
N
S
L
Y
L
Y
Y
K
G
L
S
K
T
Chicken
Gallus gallus
XP_426628
677
75184
Y529
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001083011
694
77646
Y546
A
D
H
C
V
H
Y
Y
D
L
R
N
A
K
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001183774
266
30123
L119
S
D
D
A
K
V
K
L
W
S
T
N
Q
E
Q
Poplar Tree
Populus trichocarpa
XP_002331573
602
68684
D455
H
V
A
V
G
S
A
D
H
H
I
H
Y
Y
D
Maize
Zea mays
NP_001145835
655
73346
H508
V
A
V
G
S
A
D
H
H
I
H
Y
F
D
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43254
675
76169
H528
I
A
V
G
S
A
D
H
H
I
H
Y
Y
D
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
99.1
96.8
N.A.
97.5
58.8
N.A.
82.9
88.3
N.A.
79.6
N.A.
N.A.
N.A.
N.A.
28.7
Protein Similarity:
100
97.2
99.1
97.1
N.A.
97.8
58.8
N.A.
83.4
89.5
N.A.
85
N.A.
N.A.
N.A.
N.A.
32.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
13.3
100
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
46.6
100
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
37
38.8
N.A.
30.9
N.A.
N.A.
Protein Similarity:
54.1
55.2
N.A.
49.3
N.A.
N.A.
P-Site Identity:
0
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
6.6
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
16
8
8
0
16
8
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
8
54
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
62
8
0
0
0
16
16
54
0
0
0
0
16
8
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
16
8
0
0
0
0
0
8
0
0
0
0
% G
% His:
8
8
54
0
8
54
0
16
24
8
16
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
16
8
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
8
0
0
8
0
0
8
62
0
% K
% Leu:
0
0
0
0
8
0
8
8
8
54
0
8
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
0
0
0
0
8
62
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
62
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
54
0
0
0
0
% R
% Ser:
8
0
0
8
16
8
0
0
0
8
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
8
47
0
8
% T
% Val:
8
8
16
16
54
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
16
62
62
8
0
0
16
16
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _