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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-3
All Species:
3.94
Human Site:
Y246
Identified Species:
7.88
UniProt:
Q8TAU0
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TAU0
NP_660328.2
364
38406
Y246
V
T
P
S
A
Q
A
Y
G
A
P
Y
S
V
G
Chimpanzee
Pan troglodytes
XP_001166828
293
32446
R178
R
Y
L
S
A
P
E
R
E
H
L
A
S
S
L
Rhesus Macaque
Macaca mulatta
XP_001106216
296
32619
L181
S
A
P
E
R
E
H
L
A
S
S
L
K
L
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P97334
362
38072
Y243
V
T
P
S
A
Q
T
Y
G
S
P
Y
G
V
G
Rat
Rattus norvegicus
O35767
318
34318
L203
R
Q
D
Q
T
L
E
L
L
G
P
P
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513144
199
22401
P84
Y
L
N
S
L
A
A
P
E
G
H
G
E
A
G
Chicken
Gallus gallus
Q90788
294
33054
Q179
Y
K
C
K
R
Q
R
Q
D
Q
T
L
E
M
V
Frog
Xenopus laevis
P42583
299
34079
Q184
Y
K
C
K
R
Q
R
Q
D
Q
T
L
E
M
V
Zebra Danio
Brachydanio rerio
Q90481
269
30288
E154
Q
R
Y
L
S
A
P
E
R
E
H
L
A
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
Q353
S
G
N
N
S
S
S
Q
S
Q
Q
H
G
T
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
A184
A
P
E
R
E
Q
L
A
N
S
I
R
L
T
P
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
K228
K
L
T
P
T
Q
V
K
I
W
F
Q
N
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.7
76.9
N.A.
N.A.
90.6
45.3
N.A.
43.4
46.4
43.9
32.4
N.A.
26.9
N.A.
25.5
30.2
Protein Similarity:
100
78.8
78.5
N.A.
N.A.
93.1
54.1
N.A.
46.9
57.4
56.8
43.1
N.A.
39.5
N.A.
34.3
43.9
P-Site Identity:
100
20
6.6
N.A.
N.A.
80
6.6
N.A.
20
6.6
6.6
0
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
20
26.6
N.A.
N.A.
86.6
6.6
N.A.
20
13.3
13.3
13.3
N.A.
26.6
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
0
25
17
17
9
9
9
0
9
9
9
0
% A
% Cys:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
17
0
0
0
0
0
0
% D
% Glu:
0
0
9
9
9
9
17
9
17
9
0
0
25
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
17
17
0
9
17
0
25
% G
% His:
0
0
0
0
0
0
9
0
0
9
17
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% I
% Lys:
9
17
0
17
0
0
0
9
0
0
0
0
9
0
0
% K
% Leu:
0
17
9
9
9
9
9
17
9
0
9
34
9
9
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% M
% Asn:
0
0
17
9
0
0
0
0
9
0
0
0
9
0
9
% N
% Pro:
0
9
25
9
0
9
9
9
0
0
25
9
9
9
17
% P
% Gln:
9
9
0
9
0
50
0
25
0
25
9
9
0
0
0
% Q
% Arg:
17
9
0
9
25
0
17
9
9
0
0
9
0
9
9
% R
% Ser:
17
0
0
34
17
9
9
0
9
25
9
0
17
17
0
% S
% Thr:
0
17
9
0
17
0
9
0
0
0
17
0
0
17
9
% T
% Val:
17
0
0
0
0
0
9
0
0
0
0
0
0
17
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
25
9
9
0
0
0
0
17
0
0
0
17
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _