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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHDC4
All Species:
33.94
Human Site:
S493
Identified Species:
62.22
UniProt:
Q8TBB5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBB5
NP_060036.2
520
57892
S493
E
W
L
E
E
T
D
S
E
E
D
S
E
E
V
Chimpanzee
Pan troglodytes
XP_001157133
541
60088
S493
E
W
L
E
E
T
D
S
E
E
D
S
E
E
V
Rhesus Macaque
Macaca mulatta
XP_001086874
522
58135
S493
E
W
L
E
E
T
D
S
E
E
D
S
E
E
V
Dog
Lupus familis
XP_546788
667
72888
S602
E
W
L
E
E
S
D
S
E
E
D
S
N
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q921I2
584
64842
S493
E
W
L
E
E
S
D
S
E
E
D
S
S
S
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508869
624
70162
S540
E
W
L
E
E
S
D
S
E
D
G
D
D
G
E
Chicken
Gallus gallus
NP_001025749
579
65046
S494
E
W
L
E
E
S
E
S
E
E
E
E
D
D
V
Frog
Xenopus laevis
NP_001079516
578
65206
S495
E
W
L
D
E
S
D
S
E
D
E
E
A
E
G
Zebra Danio
Brachydanio rerio
NP_001119902
585
65979
S498
E
W
L
E
E
S
E
S
E
D
E
K
E
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648590
509
56333
S483
K
G
H
E
W
E
D
S
D
S
S
S
S
D
E
Honey Bee
Apis mellifera
XP_624296
469
54330
R443
C
R
K
L
D
E
W
R
T
I
L
R
D
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SDM9
470
51651
K444
T
A
T
I
D
G
K
K
G
L
V
M
H
G
G
Baker's Yeast
Sacchar. cerevisiae
Q08979
651
75415
E528
E
F
E
Y
E
D
D
E
E
D
E
D
D
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
95.7
63.2
N.A.
72.7
N.A.
N.A.
62.1
69
64.3
63.4
N.A.
41.1
41.5
N.A.
N.A.
Protein Similarity:
100
94.6
97.5
70.9
N.A.
79.4
N.A.
N.A.
72.4
79.2
76.1
74
N.A.
59.6
58.4
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
73.3
N.A.
N.A.
53.3
60
53.3
60
N.A.
26.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
80
N.A.
N.A.
73.3
93.3
80
86.6
N.A.
46.6
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
27.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.7
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
16
8
70
0
8
31
39
16
31
24
8
% D
% Glu:
77
0
8
70
77
16
16
8
77
47
31
16
31
47
24
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
0
0
8
0
8
0
0
24
31
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
8
0
8
0
0
0
8
8
0
0
0
8
0
0
0
% K
% Leu:
0
0
70
8
0
0
0
0
0
8
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
8
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
47
0
77
0
8
8
47
16
8
0
% S
% Thr:
8
0
8
0
0
24
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
31
% V
% Trp:
0
70
0
0
8
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _