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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AGXT2L1 All Species: 49.09
Human Site: S145 Identified Species: 72
UniProt: Q8TBG4 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TBG4 NP_001140062.1 499 55671 S145 A Y H G H L S S L I E I S P Y
Chimpanzee Pan troglodytes XP_001137764 499 55702 S145 A Y H G H L S S L I E I S P Y
Rhesus Macaque Macaca mulatta XP_001087348 499 55544 S145 A S H G H L S S L I E I S P Y
Dog Lupus familis XP_535690 497 55971 S176 A Y H G H L S S L I E I S P Y
Cat Felis silvestris
Mouse Mus musculus Q8BWU8 499 55478 S145 A Y H G H L S S L I E I S P Y
Rat Rattus norvegicus Q64565 512 57182 N172 V N S G S E A N D L A M V M A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518449 556 61343 S204 A Y H G H V T S L I E I S P Y
Chicken Gallus gallus XP_426301 505 55954 S149 A Y H G H V T S L I D I S P Y
Frog Xenopus laevis Q6DEB1 509 56952 S145 A Y H G H V T S L I D I S P Y
Zebra Danio Brachydanio rerio Q7SY54 492 54717 S146 A Y H G H V S S L I D I S P Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VU95 494 54265 S156 A Y H G H L Q S V M E V S P Y
Honey Bee Apis mellifera XP_392348 482 53855 S148 A Y H G H L T S M I D I S P Y
Nematode Worm Caenorhab. elegans P91408 467 51626 N135 C N S G S E A N D L A L R L A
Sea Urchin Strong. purpuratus XP_001187418 531 59206 S148 A Y H G H T S S V I D I S P Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q940M2 476 51934 Q128 T E Q S K L L Q H A T T I Y L
Baker's Yeast Sacchar. cerevisiae P07991 424 46067 G110 T V L P M N T G A E A V E T A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 96.1 74.5 N.A. 83.9 35.5 N.A. 68.8 72.6 71.9 66.1 N.A. 52.5 54.9 44.4 49.3
Protein Similarity: 100 99.4 97.5 81.7 N.A. 92.1 51.5 N.A. 76.4 84.5 85.2 80.9 N.A. 70.1 73.5 62.5 66.2
P-Site Identity: 100 100 93.3 100 N.A. 100 6.6 N.A. 86.6 80 80 86.6 N.A. 73.3 80 6.6 80
P-Site Similarity: 100 100 93.3 100 N.A. 100 33.3 N.A. 100 100 100 100 N.A. 93.3 100 33.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. 40.6 25 N.A.
Protein Similarity: N.A. N.A. N.A. 55.9 43.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 75 0 0 0 0 0 13 0 7 7 19 0 0 0 19 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 13 0 32 0 0 0 0 % D
% Glu: 0 7 0 0 0 13 0 0 0 7 44 0 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 88 0 0 0 7 0 0 0 0 0 0 0 % G
% His: 0 0 75 0 75 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 69 0 69 7 0 0 % I
% Lys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 7 0 0 50 7 0 57 13 0 7 0 7 7 % L
% Met: 0 0 0 0 7 0 0 0 7 7 0 7 0 7 0 % M
% Asn: 0 13 0 0 0 7 0 13 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 0 0 0 0 0 0 0 0 75 0 % P
% Gln: 0 0 7 0 0 0 7 7 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % R
% Ser: 0 7 13 7 13 0 44 75 0 0 0 0 75 0 0 % S
% Thr: 13 0 0 0 0 7 32 0 0 0 7 7 0 7 0 % T
% Val: 7 7 0 0 0 25 0 0 13 0 0 13 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 69 0 0 0 0 0 0 0 0 0 0 0 7 75 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _