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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD6
All Species:
3.94
Human Site:
S185
Identified Species:
8.67
UniProt:
Q8TBK2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBK2
NP_001153777
473
53020
S185
E
K
D
L
A
N
I
S
S
E
Y
Q
S
I
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102146
481
54024
R186
E
K
D
L
A
N
I
R
S
E
Y
H
S
I
V
Dog
Lupus familis
XP_544379
453
51445
R165
E
K
D
L
A
N
I
R
S
E
Y
Y
S
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CWY3
473
52942
R185
E
K
D
L
V
N
I
R
S
E
Y
Y
S
I
V
Rat
Rattus norvegicus
NP_001099637
474
53343
R186
E
K
D
L
V
N
I
R
S
E
Y
Y
S
I
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507526
513
58286
S225
E
K
D
L
A
N
I
S
H
E
Y
S
S
I
V
Chicken
Gallus gallus
Q5ZK17
447
50631
I163
I
Q
L
E
Y
S
S
I
I
L
P
F
M
K
S
Frog
Xenopus laevis
Q6INM2
455
52340
E161
R
N
D
L
K
N
I
E
E
E
Y
N
S
I
V
Zebra Danio
Brachydanio rerio
Q803K4
460
52989
Q159
I
T
D
L
R
K
L
Q
D
E
Y
N
S
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001181160
466
53174
D173
Q
R
D
L
R
N
I
D
R
D
Y
H
D
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12504
494
57270
G163
I
K
S
I
K
Q
I
G
G
E
F
S
R
V
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
94.8
83.9
N.A.
77.1
77.6
N.A.
61.4
64.4
56.2
49
N.A.
N.A.
N.A.
N.A.
40.8
Protein Similarity:
100
N.A.
95.8
86.8
N.A.
83.3
82.9
N.A.
71.1
76.1
71.2
67.8
N.A.
N.A.
N.A.
N.A.
57.7
P-Site Identity:
100
N.A.
86.6
86.6
N.A.
80
80
N.A.
86.6
0
60
40
N.A.
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
N.A.
86.6
86.6
N.A.
80
80
N.A.
86.6
13.3
60
53.3
N.A.
N.A.
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
37
0
0
0
0
0
0
0
0
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
82
0
0
0
0
10
10
10
0
0
10
0
0
% D
% Glu:
55
0
0
10
0
0
0
10
10
82
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
19
0
0
0
% H
% Ile:
28
0
0
10
0
0
82
10
10
0
0
0
0
64
0
% I
% Lys:
0
64
0
0
19
10
0
0
0
0
0
0
0
10
0
% K
% Leu:
0
0
10
82
0
0
10
0
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
10
0
0
0
73
0
0
0
0
0
19
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
10
10
0
0
0
10
0
10
0
0
0
10
0
0
0
% Q
% Arg:
10
10
0
0
19
0
0
37
10
0
0
0
10
0
0
% R
% Ser:
0
0
10
0
0
10
10
19
46
0
0
19
73
0
10
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
19
0
0
0
0
0
0
0
0
28
73
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
82
28
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _