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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2C
All Species:
23.33
Human Site:
S26
Identified Species:
46.67
UniProt:
Q8TBX8
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBX8
NP_001139731.1
421
47286
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Chimpanzee
Pan troglodytes
XP_001168018
421
47239
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Rhesus Macaque
Macaca mulatta
XP_001116157
421
47338
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Dog
Lupus familis
XP_531649
393
44442
V26
P
H
W
L
P
V
L
V
L
V
Y
Q
I
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q91XU3
421
47317
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Rat
Rattus norvegicus
O88370
420
47030
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
T30
A
D
T
P
K
G
H
T
L
V
Q
E
I
L
Q
Chicken
Gallus gallus
Q5F356
405
46073
K26
K
K
H
F
V
V
Q
K
V
K
L
F
R
A
S
Frog
Xenopus laevis
Q5PQ01
419
47633
T29
L
S
A
T
T
A
K
T
K
T
K
K
K
H
F
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
H27
K
T
K
T
K
K
R
H
F
M
Q
Q
K
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
V26
F
R
V
K
H
Q
K
V
K
L
F
R
A
N
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
T263
Y
P
D
D
Y
W
S
T
S
D
P
P
R
D
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
85.9
N.A.
96.1
95.4
N.A.
54.7
64.1
76.2
69.5
N.A.
N.A.
51.3
N.A.
N.A.
Protein Similarity:
100
100
99.5
88.5
N.A.
97.6
97.3
N.A.
67.2
77.9
88.5
83.3
N.A.
N.A.
67.4
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
0
6.6
46.6
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
20
13.3
53.3
20
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
9
42
0
0
0
0
0
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
9
9
0
0
0
0
0
9
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
17
% E
% Phe:
9
0
0
50
0
42
0
0
9
0
9
9
0
0
59
% F
% Gly:
42
0
42
0
42
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
9
9
0
9
0
9
9
0
0
0
0
0
50
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% I
% Lys:
17
9
9
9
17
9
17
9
59
9
50
50
59
0
9
% K
% Leu:
9
0
0
9
0
0
9
0
17
9
9
0
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% N
% Pro:
9
50
0
9
9
0
0
0
0
0
9
9
0
0
0
% P
% Gln:
0
0
0
0
0
9
9
0
0
0
17
17
0
0
9
% Q
% Arg:
0
9
0
0
0
0
9
0
0
0
0
9
17
0
0
% R
% Ser:
0
9
0
0
0
0
9
42
9
0
0
0
0
0
9
% S
% Thr:
0
9
9
17
9
0
0
25
0
50
0
0
0
0
0
% T
% Val:
0
0
9
0
9
17
0
17
9
17
0
0
0
9
0
% V
% Trp:
0
0
9
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _