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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2C
All Species:
38.79
Human Site:
Y169
Identified Species:
77.58
UniProt:
Q8TBX8
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBX8
NP_001139731.1
421
47286
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Chimpanzee
Pan troglodytes
XP_001168018
421
47239
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Rhesus Macaque
Macaca mulatta
XP_001116157
421
47338
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Dog
Lupus familis
XP_531649
393
44442
L153
V
K
C
H
G
N
T
L
L
P
Q
F
L
G
M
Cat
Felis silvestris
Mouse
Mus musculus
Q91XU3
421
47317
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Rat
Rattus norvegicus
O88370
420
47030
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
Y231
M
H
N
I
L
K
K
Y
H
Q
Y
I
V
E
C
Chicken
Gallus gallus
Q5F356
405
46073
Y161
M
H
N
I
L
K
K
Y
H
Q
F
I
V
E
C
Frog
Xenopus laevis
Q5PQ01
419
47633
Y173
M
H
I
I
L
S
H
Y
H
Q
H
I
V
K
C
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
Y165
M
H
N
I
L
S
E
Y
H
Q
H
I
V
K
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
Y160
M
N
S
F
L
K
H
Y
H
P
Y
I
V
E
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
Y477
L
L
R
M
L
P
R
Y
Y
E
H
V
G
D
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
85.9
N.A.
96.1
95.4
N.A.
54.7
64.1
76.2
69.5
N.A.
N.A.
51.3
N.A.
N.A.
Protein Similarity:
100
100
99.5
88.5
N.A.
97.6
97.3
N.A.
67.2
77.9
88.5
83.3
N.A.
N.A.
67.4
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
66.6
60
73.3
73.3
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
80
80
86.6
86.6
N.A.
N.A.
73.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
75
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
9
0
0
9
0
0
0
25
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
9
9
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
0
0
0
0
0
9
9
0
% G
% His:
0
75
0
9
0
0
17
0
84
0
25
0
0
0
0
% H
% Ile:
0
0
9
34
0
0
0
0
0
0
0
84
0
0
0
% I
% Lys:
0
9
0
0
0
25
17
0
0
0
0
0
0
59
0
% K
% Leu:
9
9
0
0
92
0
0
9
9
0
0
0
9
0
0
% L
% Met:
84
0
0
9
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
9
25
42
0
9
42
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
0
17
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
75
9
0
0
0
0
% Q
% Arg:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
9
% R
% Ser:
0
0
50
0
0
59
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
0
0
0
9
84
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
9
0
59
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _