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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2C
All Species:
22.73
Human Site:
Y281
Identified Species:
45.45
UniProt:
Q8TBX8
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBX8
NP_001139731.1
421
47286
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Chimpanzee
Pan troglodytes
XP_001168018
421
47239
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Rhesus Macaque
Macaca mulatta
XP_001116157
421
47338
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Dog
Lupus familis
XP_531649
393
44442
Y253
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Cat
Felis silvestris
Mouse
Mus musculus
Q91XU3
421
47317
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Rat
Rattus norvegicus
O88370
420
47030
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
L335
L
K
K
D
V
E
F
L
A
Q
L
K
L
M
D
Chicken
Gallus gallus
Q5F356
405
46073
L265
L
K
K
D
V
E
F
L
A
Q
L
K
L
M
D
Frog
Xenopus laevis
Q5PQ01
419
47633
Q279
R
D
V
D
F
L
V
Q
L
K
L
M
D
Y
S
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
D276
L
V
K
L
K
I
M
D
Y
S
L
L
L
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
L275
H
L
M
D
Y
S
L
L
L
G
L
H
D
C
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
E627
V
D
V
N
L
P
R
E
P
S
I
P
P
K
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
85.9
N.A.
96.1
95.4
N.A.
54.7
64.1
76.2
69.5
N.A.
N.A.
51.3
N.A.
N.A.
Protein Similarity:
100
100
99.5
88.5
N.A.
97.6
97.3
N.A.
67.2
77.9
88.5
83.3
N.A.
N.A.
67.4
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
6.6
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
40
40
26.6
26.6
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
17
0
34
0
0
50
9
0
0
0
0
17
0
17
% D
% Glu:
0
0
0
0
0
17
0
9
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
17
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
9
0
0
50
9
9
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
50
% H
% Ile:
0
0
0
0
50
9
0
0
0
0
9
0
0
50
9
% I
% Lys:
0
17
25
50
9
0
0
0
0
9
0
17
0
9
0
% K
% Leu:
25
9
50
9
9
9
9
25
17
50
92
59
25
0
0
% L
% Met:
0
0
9
0
0
50
9
0
0
0
0
9
0
17
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
9
0
0
9
9
0
0
% P
% Gln:
0
50
0
0
0
0
0
9
0
17
0
0
0
0
0
% Q
% Arg:
9
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
9
0
0
50
17
0
0
0
0
9
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
59
9
17
0
17
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
50
9
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _