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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2C
All Species:
36.36
Human Site:
Y408
Identified Species:
72.73
UniProt:
Q8TBX8
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBX8
NP_001139731.1
421
47286
Y408
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Chimpanzee
Pan troglodytes
XP_001168018
421
47239
Y408
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Rhesus Macaque
Macaca mulatta
XP_001116157
421
47338
Y408
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Dog
Lupus familis
XP_531649
393
44442
Y380
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q91XU3
421
47317
Y408
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Rat
Rattus norvegicus
O88370
420
47030
A408
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
Y462
S
T
V
N
P
E
Q
Y
S
K
R
F
L
D
F
Chicken
Gallus gallus
Q5F356
405
46073
Y392
S
T
V
N
P
E
Q
Y
S
K
R
F
L
D
F
Frog
Xenopus laevis
Q5PQ01
419
47633
Y406
S
T
V
H
P
D
Q
Y
G
K
R
F
L
E
F
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
Y403
S
T
V
H
P
E
Q
Y
A
K
R
F
R
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
Q402
I
S
T
C
D
P
E
Q
Y
G
K
R
F
I
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
S754
A
I
E
P
T
L
Y
S
K
R
F
I
D
F
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
85.9
N.A.
96.1
95.4
N.A.
54.7
64.1
76.2
69.5
N.A.
N.A.
51.3
N.A.
N.A.
Protein Similarity:
100
100
99.5
88.5
N.A.
97.6
97.3
N.A.
67.2
77.9
88.5
83.3
N.A.
N.A.
67.4
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
86.6
86.6
80
86.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
93.3
93.3
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
9
50
0
0
0
0
0
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
9
0
0
0
0
0
0
17
59
0
% D
% Glu:
0
0
9
0
9
67
9
0
0
0
0
0
0
17
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
17
75
9
17
75
% F
% Gly:
0
0
0
0
0
0
0
0
9
9
0
0
0
0
0
% G
% His:
0
0
9
59
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
0
0
0
0
0
0
0
0
0
9
0
9
9
% I
% Lys:
0
0
0
0
0
0
0
0
17
75
9
0
0
0
0
% K
% Leu:
0
0
0
0
0
9
0
0
0
0
0
9
67
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
17
75
9
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
75
9
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
17
75
9
9
0
0
% R
% Ser:
75
9
0
0
0
0
0
9
17
0
0
0
0
0
0
% S
% Thr:
9
75
9
0
9
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
75
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
17
75
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _