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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM1
All Species:
20.3
Human Site:
S398
Identified Species:
49.63
UniProt:
Q8TC05
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC05
NP_064513.1
714
80735
S398
D
L
A
G
D
P
T
S
H
K
T
L
Q
K
C
Chimpanzee
Pan troglodytes
XP_509206
714
80684
S398
D
L
A
G
D
P
T
S
H
K
T
L
Q
K
C
Rhesus Macaque
Macaca mulatta
XP_001117173
720
81656
S399
D
L
A
G
D
T
T
S
H
K
T
L
Q
K
C
Dog
Lupus familis
XP_531669
782
87790
S467
D
L
A
G
D
P
T
S
H
K
T
L
Q
K
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9D067
708
79671
N399
D
L
A
G
D
L
T
N
H
R
T
P
Q
K
H
Rat
Rattus norvegicus
Q5PQN4
719
80679
S408
D
L
A
G
D
L
T
S
H
R
T
L
Q
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511246
686
76752
H386
D
L
A
G
L
S
P
H
Q
G
S
A
A
V
E
Chicken
Gallus gallus
Q5ZMW6
691
77332
S378
K
M
L
Q
Q
P
G
S
R
E
Q
S
H
Q
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RHU7
656
74275
T374
E
S
E
A
C
R
S
T
S
H
I
I
E
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799039
812
89995
K460
S
E
K
K
D
E
P
K
E
G
A
R
P
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
94.4
73.7
N.A.
70.3
68.5
N.A.
50.4
44.5
N.A.
36.4
N.A.
N.A.
N.A.
N.A.
21.1
Protein Similarity:
100
99.3
96.3
81.1
N.A.
79.4
77.7
N.A.
64.4
60.3
N.A.
52.9
N.A.
N.A.
N.A.
N.A.
37.5
P-Site Identity:
100
100
93.3
100
N.A.
66.6
80
N.A.
26.6
13.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
100
N.A.
80
86.6
N.A.
33.3
33.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
70
10
0
0
0
0
0
0
10
10
10
10
10
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
40
% C
% Asp:
70
0
0
0
70
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
10
10
10
0
0
10
0
0
10
10
0
0
10
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
70
0
0
10
0
0
20
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
60
10
0
0
10
0
20
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% I
% Lys:
10
0
10
10
0
0
0
10
0
40
0
0
0
60
0
% K
% Leu:
0
70
10
0
10
20
0
0
0
0
0
50
0
0
10
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
40
20
0
0
0
0
10
10
0
0
% P
% Gln:
0
0
0
10
10
0
0
0
10
0
10
0
60
10
0
% Q
% Arg:
0
0
0
0
0
10
0
0
10
20
0
10
0
0
0
% R
% Ser:
10
10
0
0
0
10
10
60
10
0
10
10
0
10
0
% S
% Thr:
0
0
0
0
0
10
60
10
0
0
60
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _