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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM1
All Species:
3.94
Human Site:
S492
Identified Species:
9.63
UniProt:
Q8TC05
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC05
NP_064513.1
714
80735
S492
K
L
D
V
R
E
K
S
K
A
D
K
M
K
E
Chimpanzee
Pan troglodytes
XP_509206
714
80684
S492
K
S
D
V
H
E
K
S
K
A
D
K
M
K
E
Rhesus Macaque
Macaca mulatta
XP_001117173
720
81656
K498
L
D
V
H
E
K
S
K
A
D
K
M
K
E
G
Dog
Lupus familis
XP_531669
782
87790
E559
L
E
V
H
E
K
S
E
A
D
K
I
K
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9D067
708
79671
P488
E
K
P
D
T
Q
T
P
K
A
D
R
L
T
E
Rat
Rattus norvegicus
Q5PQN4
719
80679
K499
K
V
D
M
Q
T
S
K
A
D
G
P
T
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511246
686
76752
L479
E
D
G
E
N
A
S
L
Q
S
A
G
L
D
R
Chicken
Gallus gallus
Q5ZMW6
691
77332
E467
N
S
P
A
A
V
S
E
S
S
S
V
S
S
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RHU7
656
74275
N454
D
K
E
G
K
T
R
N
E
N
G
M
E
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799039
812
89995
R590
K
T
T
V
T
Y
P
R
Q
G
E
L
M
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
94.4
73.7
N.A.
70.3
68.5
N.A.
50.4
44.5
N.A.
36.4
N.A.
N.A.
N.A.
N.A.
21.1
Protein Similarity:
100
99.3
96.3
81.1
N.A.
79.4
77.7
N.A.
64.4
60.3
N.A.
52.9
N.A.
N.A.
N.A.
N.A.
37.5
P-Site Identity:
100
86.6
0
0
N.A.
26.6
13.3
N.A.
0
6.6
N.A.
0
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
86.6
13.3
13.3
N.A.
53.3
40
N.A.
26.6
13.3
N.A.
40
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
10
10
0
0
30
30
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
20
30
10
0
0
0
0
0
30
30
0
0
10
0
% D
% Glu:
20
10
10
10
20
20
0
20
10
0
10
0
10
30
40
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
0
0
0
0
0
10
20
10
0
0
30
% G
% His:
0
0
0
20
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
40
20
0
0
10
20
20
20
30
0
20
20
20
30
0
% K
% Leu:
20
10
0
0
0
0
0
10
0
0
0
10
20
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
20
30
0
0
% M
% Asn:
10
0
0
0
10
0
0
10
0
10
0
0
0
0
10
% N
% Pro:
0
0
20
0
0
0
10
10
0
0
0
10
0
0
10
% P
% Gln:
0
0
0
0
10
10
0
0
20
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
0
10
10
0
0
0
10
0
10
10
% R
% Ser:
0
20
0
0
0
0
50
20
10
20
10
0
10
10
0
% S
% Thr:
0
10
10
0
20
20
10
0
0
0
0
0
10
10
0
% T
% Val:
0
10
20
30
0
10
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _