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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM1
All Species:
20.91
Human Site:
S545
Identified Species:
51.11
UniProt:
Q8TC05
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC05
NP_064513.1
714
80735
S545
G
A
V
L
V
S
P
S
K
M
K
P
P
A
P
Chimpanzee
Pan troglodytes
XP_509206
714
80684
S545
G
A
V
L
V
S
P
S
K
M
K
P
P
A
P
Rhesus Macaque
Macaca mulatta
XP_001117173
720
81656
S551
G
A
V
L
V
S
P
S
K
M
K
P
P
A
P
Dog
Lupus familis
XP_531669
782
87790
S612
G
A
V
L
V
S
P
S
K
V
R
P
S
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9D067
708
79671
S541
G
A
V
L
V
S
P
S
K
V
K
P
P
G
L
Rat
Rattus norvegicus
Q5PQN4
719
80679
K552
A
V
L
V
S
P
A
K
A
K
P
S
A
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511246
686
76752
T532
G
A
V
L
V
S
P
T
K
R
K
P
S
Y
P
Chicken
Gallus gallus
Q5ZMW6
691
77332
Q520
F
K
S
S
T
S
Q
Q
R
M
R
S
L
G
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RHU7
656
74275
T507
Q
R
T
H
H
D
R
T
T
P
S
I
D
F
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799039
812
89995
G643
L
D
R
T
L
T
R
G
Q
Q
T
P
P
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
94.4
73.7
N.A.
70.3
68.5
N.A.
50.4
44.5
N.A.
36.4
N.A.
N.A.
N.A.
N.A.
21.1
Protein Similarity:
100
99.3
96.3
81.1
N.A.
79.4
77.7
N.A.
64.4
60.3
N.A.
52.9
N.A.
N.A.
N.A.
N.A.
37.5
P-Site Identity:
100
100
100
73.3
N.A.
80
0
N.A.
73.3
13.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
13.3
N.A.
80
26.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
60
0
0
0
0
10
0
10
0
0
0
10
30
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
10
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% F
% Gly:
60
0
0
0
0
0
0
10
0
0
0
0
0
20
0
% G
% His:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
10
60
10
50
0
0
0
0
% K
% Leu:
10
0
10
60
10
0
0
0
0
0
0
0
10
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
40
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% N
% Pro:
0
0
0
0
0
10
60
0
0
10
10
70
50
0
50
% P
% Gln:
10
0
0
0
0
0
10
10
10
10
0
0
0
0
0
% Q
% Arg:
0
10
10
0
0
0
20
0
10
10
20
0
0
10
0
% R
% Ser:
0
0
10
10
10
70
0
50
0
0
10
20
20
0
0
% S
% Thr:
0
0
10
10
10
10
0
20
10
0
10
0
0
0
10
% T
% Val:
0
10
60
10
60
0
0
0
0
20
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _