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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM1
All Species:
9.09
Human Site:
Y621
Identified Species:
22.22
UniProt:
Q8TC05
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC05
NP_064513.1
714
80735
Y621
P
V
S
K
I
P
K
Y
P
T
N
P
P
G
Q
Chimpanzee
Pan troglodytes
XP_509206
714
80684
Y621
P
V
S
K
I
P
K
Y
P
T
N
P
P
G
Q
Rhesus Macaque
Macaca mulatta
XP_001117173
720
81656
Y627
P
V
S
K
I
P
E
Y
P
T
N
P
P
G
Q
Dog
Lupus familis
XP_531669
782
87790
E688
L
P
V
S
K
I
P
E
Y
P
T
N
T
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9D067
708
79671
R617
P
V
S
K
I
L
D
R
Q
P
S
T
P
G
Q
Rat
Rattus norvegicus
Q5PQN4
719
80679
H628
P
V
L
K
N
L
D
H
Q
T
N
T
P
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511246
686
76752
W608
R
P
P
A
P
S
L
W
H
P
S
R
R
I
R
Chicken
Gallus gallus
Q5ZMW6
691
77332
R596
I
N
S
A
Y
Q
E
R
S
S
T
P
P
V
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RHU7
656
74275
N583
A
N
A
A
P
P
A
N
R
I
Q
G
T
M
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799039
812
89995
G719
T
W
A
A
P
W
A
G
L
K
T
A
P
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
94.4
73.7
N.A.
70.3
68.5
N.A.
50.4
44.5
N.A.
36.4
N.A.
N.A.
N.A.
N.A.
21.1
Protein Similarity:
100
99.3
96.3
81.1
N.A.
79.4
77.7
N.A.
64.4
60.3
N.A.
52.9
N.A.
N.A.
N.A.
N.A.
37.5
P-Site Identity:
100
100
93.3
0
N.A.
53.3
53.3
N.A.
0
20
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
0
N.A.
60
60
N.A.
20
33.3
N.A.
20
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
20
40
0
0
20
0
0
0
0
10
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
20
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
10
0
50
10
% G
% His:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
40
10
0
0
0
10
0
0
0
10
0
% I
% Lys:
0
0
0
50
10
0
20
0
0
10
0
0
0
0
0
% K
% Leu:
10
0
10
0
0
20
10
0
10
0
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
20
0
0
10
0
0
10
0
0
40
10
0
0
0
% N
% Pro:
50
20
10
0
30
40
10
0
30
30
0
40
70
20
0
% P
% Gln:
0
0
0
0
0
10
0
0
20
0
10
0
0
0
50
% Q
% Arg:
10
0
0
0
0
0
0
20
10
0
0
10
10
0
20
% R
% Ser:
0
0
50
10
0
10
0
0
10
10
20
0
0
0
0
% S
% Thr:
10
0
0
0
0
0
0
0
0
40
30
20
20
0
0
% T
% Val:
0
50
10
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
10
0
0
0
10
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
30
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _