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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL2
All Species:
7.58
Human Site:
T143
Identified Species:
15.15
UniProt:
Q8TC59
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC59
NP_001129193.1
973
109849
T143
T
S
V
G
W
S
R
T
L
G
R
G
S
S
D
Chimpanzee
Pan troglodytes
XP_528083
973
109707
T143
A
S
V
G
W
S
R
T
L
G
R
G
S
S
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543251
972
109396
M140
A
C
V
G
W
N
R
M
L
G
R
G
N
S
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8CDG1
971
109470
M141
A
S
V
G
W
S
R
M
L
G
R
G
S
S
E
Rat
Rattus norvegicus
Q4G033
848
95953
L110
L
A
T
N
L
F
H
L
D
L
P
Q
D
W
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517374
945
106464
S139
T
V
G
L
G
R
A
S
P
K
I
H
N
D
I
Chicken
Gallus gallus
A6N7Y9
867
99268
L129
L
I
A
N
F
F
R
L
T
S
R
P
Q
W
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A2CEI6
1046
116189
I216
E
V
R
S
E
E
S
I
S
F
L
G
R
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
R105
M
L
Q
T
N
F
F
R
L
K
T
K
P
E
W
Honey Bee
Apis mellifera
XP_001120996
812
92430
Y74
P
A
K
G
L
F
N
Y
E
V
K
F
N
P
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001107667
959
107692
S134
T
P
S
P
A
R
Q
S
P
S
P
P
G
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJK3
997
111116
P138
K
P
E
M
T
S
L
P
P
A
S
S
K
A
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
90.3
N.A.
87.9
34.6
N.A.
71.3
38.6
N.A.
55
N.A.
29.7
32.9
N.A.
41.9
Protein Similarity:
100
99.2
N.A.
93.4
N.A.
93
52.7
N.A.
80.9
57.1
N.A.
69.3
N.A.
49.1
51
N.A.
61
P-Site Identity:
100
93.3
N.A.
60
N.A.
80
0
N.A.
6.6
13.3
N.A.
6.6
N.A.
6.6
13.3
N.A.
6.6
P-Site Similarity:
100
93.3
N.A.
80
N.A.
86.6
6.6
N.A.
20
20
N.A.
6.6
N.A.
6.6
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
17
9
0
9
0
9
0
0
9
0
0
0
9
9
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
9
0
0
0
9
9
25
% D
% Glu:
9
0
9
0
9
9
0
0
9
0
0
0
0
9
9
% E
% Phe:
0
0
0
0
9
34
9
0
0
9
0
9
0
0
9
% F
% Gly:
0
0
9
42
9
0
0
0
0
34
0
42
9
9
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
9
0
0
9
0
0
0
9
% I
% Lys:
9
0
9
0
0
0
0
0
0
17
9
9
9
9
0
% K
% Leu:
17
9
0
9
17
0
9
17
42
9
9
0
0
0
0
% L
% Met:
9
0
0
9
0
0
0
17
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
9
9
9
0
0
0
0
0
25
0
9
% N
% Pro:
9
17
0
9
0
0
0
9
25
0
17
17
9
9
0
% P
% Gln:
0
0
9
0
0
0
9
0
0
0
0
9
9
0
9
% Q
% Arg:
0
0
9
0
0
17
42
9
0
0
42
0
9
0
0
% R
% Ser:
0
25
9
9
0
34
9
17
9
17
9
9
25
34
9
% S
% Thr:
25
0
9
9
9
0
0
17
9
0
9
0
0
0
0
% T
% Val:
0
17
34
0
0
0
0
0
0
9
0
0
0
0
9
% V
% Trp:
0
0
0
0
34
0
0
0
0
0
0
0
0
17
9
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _