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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL2
All Species:
19.7
Human Site:
Y243
Identified Species:
39.39
UniProt:
Q8TC59
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC59
NP_001129193.1
973
109849
Y243
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
P
N
Chimpanzee
Pan troglodytes
XP_528083
973
109707
Y243
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
P
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543251
972
109396
Y243
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
P
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8CDG1
971
109470
Y241
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
P
S
Rat
Rattus norvegicus
Q4G033
848
95953
F209
N
V
I
F
R
K
I
F
K
K
L
S
M
Y
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517374
945
106464
S238
G
M
L
K
D
H
Q
S
V
T
G
D
V
T
A
Chicken
Gallus gallus
A6N7Y9
867
99268
L228
N
I
I
F
R
R
L
L
K
M
M
N
F
Q
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A2CEI6
1046
116189
Y316
K
N
D
A
V
F
Q
Y
H
V
T
F
T
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
S204
L
N
L
I
L
R
R
S
M
K
G
L
N
L
E
Honey Bee
Apis mellifera
XP_001120996
812
92430
A173
L
L
G
R
V
M
R
A
L
S
L
V
R
I
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001107667
959
107692
F233
V
W
Q
Y
A
V
S
F
D
P
P
I
E
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJK3
997
111116
K250
R
A
D
G
S
S
G
K
D
R
P
F
K
V
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
90.3
N.A.
87.9
34.6
N.A.
71.3
38.6
N.A.
55
N.A.
29.7
32.9
N.A.
41.9
Protein Similarity:
100
99.2
N.A.
93.4
N.A.
93
52.7
N.A.
80.9
57.1
N.A.
69.3
N.A.
49.1
51
N.A.
61
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
0
N.A.
6.6
0
N.A.
73.3
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
13.3
N.A.
13.3
13.3
N.A.
93.3
N.A.
26.6
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
42
9
0
0
9
0
0
0
0
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
17
0
9
0
0
0
17
0
0
9
0
0
0
% D
% Glu:
0
0
34
0
0
0
0
0
0
0
0
0
9
0
9
% E
% Phe:
0
0
0
17
0
9
0
17
0
0
0
50
9
0
0
% F
% Gly:
9
0
9
9
0
0
9
0
0
0
17
0
0
0
9
% G
% His:
34
0
0
0
0
9
0
0
42
0
0
0
0
0
0
% H
% Ile:
0
9
17
9
0
0
9
0
0
0
0
9
0
9
0
% I
% Lys:
9
0
0
9
0
9
0
9
17
17
0
0
9
0
9
% K
% Leu:
17
9
17
0
9
0
9
9
9
0
17
9
0
9
0
% L
% Met:
0
9
0
0
0
9
0
0
9
9
9
0
9
0
0
% M
% Asn:
17
50
0
0
0
0
0
0
0
0
0
9
9
0
34
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
17
0
0
42
0
% P
% Gln:
0
0
9
0
0
0
50
0
0
0
0
0
0
9
17
% Q
% Arg:
9
0
0
9
17
17
17
0
0
9
0
0
9
0
0
% R
% Ser:
0
0
0
0
9
9
9
17
0
9
0
9
34
9
9
% S
% Thr:
0
0
0
0
0
0
0
0
0
9
42
0
9
9
0
% T
% Val:
9
9
0
0
50
9
0
0
9
42
0
9
9
9
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
34
0
42
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _