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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL2
All Species:
18.18
Human Site:
Y747
Identified Species:
36.36
UniProt:
Q8TC59
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TC59
NP_001129193.1
973
109849
Y747
M
V
I
G
M
D
V
Y
H
D
P
S
R
G
M
Chimpanzee
Pan troglodytes
XP_528083
973
109707
Y747
M
V
I
G
M
D
V
Y
H
D
P
S
R
G
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543251
972
109396
Y746
M
V
I
G
M
D
V
Y
H
D
P
S
R
G
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8CDG1
971
109470
Y745
M
V
I
G
M
D
V
Y
H
D
P
S
R
G
M
Rat
Rattus norvegicus
Q4G033
848
95953
V634
D
V
A
V
V
G
F
V
A
S
I
N
S
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517374
945
106464
Y719
M
V
I
G
M
D
V
Y
H
D
P
N
K
G
M
Chicken
Gallus gallus
A6N7Y9
867
99268
F653
G
K
Q
S
I
A
G
F
V
A
S
L
N
E
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A2CEI6
1046
116189
H820
M
V
I
G
V
D
V
H
H
D
T
S
K
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
L629
R
K
R
A
Y
G
A
L
I
A
S
M
D
L
Q
Honey Bee
Apis mellifera
XP_001120996
812
92430
F598
M
K
G
S
V
A
G
F
V
A
S
L
D
K
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001107667
959
107692
H733
V
I
G
I
D
V
Y
H
D
P
N
R
G
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJK3
997
111116
E746
V
A
S
M
D
W
P
E
I
N
K
Y
R
G
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
90.3
N.A.
87.9
34.6
N.A.
71.3
38.6
N.A.
55
N.A.
29.7
32.9
N.A.
41.9
Protein Similarity:
100
99.2
N.A.
93.4
N.A.
93
52.7
N.A.
80.9
57.1
N.A.
69.3
N.A.
49.1
51
N.A.
61
P-Site Identity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
86.6
0
N.A.
60
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
100
13.3
N.A.
80
N.A.
0
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
9
0
17
9
0
9
25
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
17
50
0
0
9
50
0
0
17
0
0
% D
% Glu:
0
0
0
0
0
0
0
9
0
0
0
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
9
17
0
0
0
0
0
0
0
% F
% Gly:
9
0
17
50
0
17
17
0
0
0
0
0
9
50
0
% G
% His:
0
0
0
0
0
0
0
17
50
0
0
0
0
0
0
% H
% Ile:
0
9
50
9
9
0
0
0
17
0
9
0
0
0
9
% I
% Lys:
0
25
0
0
0
0
0
0
0
0
9
0
17
25
17
% K
% Leu:
0
0
0
0
0
0
0
9
0
0
0
17
0
9
17
% L
% Met:
59
0
0
9
42
0
0
0
0
0
0
9
0
0
42
% M
% Asn:
0
0
0
0
0
0
0
0
0
9
9
17
9
0
0
% N
% Pro:
0
0
0
0
0
0
9
0
0
9
42
0
0
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
9
0
9
0
0
0
0
0
0
0
0
9
42
9
0
% R
% Ser:
0
0
9
17
0
0
0
0
0
9
25
42
9
0
9
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% T
% Val:
17
59
0
9
25
9
50
9
17
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
9
42
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _