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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC22A8 All Species: 28.48
Human Site: S259 Identified Species: 69.63
UniProt: Q8TCC7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TCC7 NP_004245.2 542 59856 S259 S S W W T P E S I R W L V L S
Chimpanzee Pan troglodytes XP_508510 554 60979 S259 S S W W T P E S I R W L V L S
Rhesus Macaque Macaca mulatta XP_001115844 542 59751 S259 S S W W T P E S I R W L V L T
Dog Lupus familis XP_533257 531 58120 S245 A A F S P S L S V Y M V F R F
Cat Felis silvestris
Mouse Mus musculus O88909 537 59228 S259 L S W W V P E S I R W L V L S
Rat Rattus norvegicus Q9R1U7 536 59168 S259 L S W W V P E S I R W L V L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521678 391 43458 G121 V R W L V L K G K P E K A L W
Chicken Gallus gallus
Frog Xenopus laevis Q66J52 552 61646 S273 Y S W W I P E S G R W L V L S
Zebra Danio Brachydanio rerio Q6NYN7 560 61953 S279 Y S W W F L E S A R W L V L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCA2 548 60985 S267 Y Y W I I P E S A R W L L M K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.1 96.3 63 N.A. 77.4 78.9 N.A. 48.3 N.A. 52.1 48.2 N.A. 32.6 N.A. N.A. N.A.
Protein Similarity: 100 94 98.5 72.3 N.A. 86.9 88.7 N.A. 57.3 N.A. 69.9 66.4 N.A. 53.6 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 6.6 N.A. 86.6 86.6 N.A. 13.3 N.A. 80 66.6 N.A. 46.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 40 N.A. 86.6 86.6 N.A. 20 N.A. 80 73.3 N.A. 60 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 0 0 20 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 80 0 0 0 10 0 0 0 0 % E
% Phe: 0 0 10 0 10 0 0 0 0 0 0 0 10 0 10 % F
% Gly: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 20 0 0 0 50 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 0 10 0 0 10 0 0 10 % K
% Leu: 20 0 0 10 0 20 10 0 0 0 0 80 10 80 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 10 70 0 0 0 10 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 0 0 0 0 80 0 0 0 10 0 % R
% Ser: 30 70 0 10 0 10 0 90 0 0 0 0 0 0 50 % S
% Thr: 0 0 0 0 30 0 0 0 0 0 0 0 0 0 20 % T
% Val: 10 0 0 0 30 0 0 0 10 0 0 10 70 0 0 % V
% Trp: 0 0 90 70 0 0 0 0 0 0 80 0 0 0 10 % W
% Tyr: 30 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _