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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CERK All Species: 17.27
Human Site: S128 Identified Species: 38
UniProt: Q8TCT0 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TCT0 NP_073603.2 537 59977 S128 E M L E K L T S R P K H L L V
Chimpanzee Pan troglodytes XP_001137835 537 59959 S128 E M L E K L T S R P K H L L V
Rhesus Macaque Macaca mulatta XP_001111087 537 59920 S128 E M L E K L T S R P K H L L V
Dog Lupus familis XP_531694 525 59050 I125 P K H L L V F I N P F G G K G
Cat Felis silvestris
Mouse Mus musculus Q8K4Q7 531 59793 S128 G L L E S L T S R P K H L L V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506327 542 60889 T128 E S L E K L T T R P K H L L V
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001074148 574 64000 R129 H S P S R P H R L L V F I N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730923 687 75672 P198 I R L H S S S P T R M R V R R
Honey Bee Apis mellifera XP_391867 431 48985 I52 L T H R P R K I L L F V N P F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797972 615 68589 G152 T A L Q Q G H G R P K R L H V
Poplar Tree Populus trichocarpa XP_002328830 627 69383 G168 A S L N L E M G R P K N L L V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.3 82.5 N.A. 83.9 N.A. N.A. 69.3 N.A. N.A. 42.3 N.A. 30.5 35 N.A. 36.7
Protein Similarity: 100 99.6 98.6 87.9 N.A. 90.3 N.A. N.A. 80.2 N.A. N.A. 59.4 N.A. 47 51.2 N.A. 57.2
P-Site Identity: 100 100 100 6.6 N.A. 80 N.A. N.A. 86.6 N.A. N.A. 0 N.A. 6.6 0 N.A. 40
P-Site Similarity: 100 100 100 13.3 N.A. 86.6 N.A. N.A. 93.3 N.A. N.A. 13.3 N.A. 20 0 N.A. 53.3
Percent
Protein Identity: 20.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 37.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 53.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 37 0 0 46 0 10 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 19 10 0 0 10 % F
% Gly: 10 0 0 0 0 10 0 19 0 0 0 10 10 0 10 % G
% His: 10 0 19 10 0 0 19 0 0 0 0 46 0 10 0 % H
% Ile: 10 0 0 0 0 0 0 19 0 0 0 0 10 0 0 % I
% Lys: 0 10 0 0 37 0 10 0 0 0 64 0 0 10 0 % K
% Leu: 10 10 73 10 19 46 0 0 19 19 0 0 64 55 0 % L
% Met: 0 28 0 0 0 0 10 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 10 0 0 10 10 10 0 % N
% Pro: 10 0 10 0 10 10 0 10 0 73 0 0 0 10 10 % P
% Gln: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 10 10 10 0 10 64 10 0 19 0 10 10 % R
% Ser: 0 28 0 10 19 10 10 37 0 0 0 0 0 0 0 % S
% Thr: 10 10 0 0 0 0 46 10 10 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 10 0 0 0 0 10 10 10 0 64 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _