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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRPM4
All Species:
9.39
Human Site:
Y519
Identified Species:
20.67
UniProt:
Q8TD43
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TD43
NP_060106.2
1214
134301
Y519
G
K
M
C
A
P
R
Y
P
S
G
G
A
W
D
Chimpanzee
Pan troglodytes
XP_512811
507
57124
Rhesus Macaque
Macaca mulatta
XP_001112814
1019
112447
T407
M
T
R
K
E
L
L
T
V
Y
S
S
E
D
G
Dog
Lupus familis
XP_541500
1267
141376
Y518
G
E
T
C
A
P
R
Y
S
A
G
G
A
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN37
1213
135742
Y519
G
E
T
C
A
P
R
Y
P
A
R
N
T
R
D
Rat
Rattus norvegicus
Q9ESQ5
1208
135322
Y519
G
E
T
C
A
P
R
Y
P
A
R
N
T
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513927
1579
182519
V548
P
K
I
Q
M
H
H
V
S
Q
V
L
R
E
L
Chicken
Gallus gallus
XP_422646
1509
172772
V570
P
R
I
Q
L
H
H
V
S
Q
V
L
R
E
L
Frog
Xenopus laevis
NP_001155066
1139
131628
F486
E
L
A
S
E
E
I
F
T
N
D
R
R
W
E
Zebra Danio
Brachydanio rerio
NP_001121711
1160
131872
N484
S
K
A
L
H
Q
K
N
L
P
D
M
D
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A8DYE2
2023
225520
A634
A
K
V
M
N
S
Y
A
N
A
C
R
K
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
41.5
72.5
81.9
N.A.
82.7
82.3
N.A.
21
24.1
31.2
43.3
N.A.
20.4
N.A.
N.A.
N.A.
Protein Similarity:
100
41.7
73.6
87.2
N.A.
88.7
88.8
N.A.
36.2
41.2
51.2
59.7
N.A.
33.4
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
66.6
N.A.
53.3
46.6
N.A.
6.6
0
6.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
0
0
80
N.A.
66.6
60
N.A.
13.3
13.3
26.6
13.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
0
37
0
0
10
0
37
0
0
19
0
0
% A
% Cys:
0
0
0
37
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
19
0
10
10
28
% D
% Glu:
10
28
0
0
19
10
0
0
0
0
0
0
10
19
10
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
37
0
0
0
0
0
0
0
0
0
19
19
0
0
10
% G
% His:
0
0
0
0
10
19
19
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
19
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
37
0
10
0
0
10
0
0
0
0
0
10
0
0
% K
% Leu:
0
10
0
10
10
10
10
0
10
0
0
19
0
0
19
% L
% Met:
10
0
10
10
10
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
10
10
10
0
19
0
0
0
% N
% Pro:
19
0
0
0
0
37
0
0
28
10
0
0
0
0
0
% P
% Gln:
0
0
0
19
0
10
0
0
0
19
0
0
0
0
0
% Q
% Arg:
0
10
10
0
0
0
37
0
0
0
19
19
28
37
10
% R
% Ser:
10
0
0
10
0
10
0
0
28
10
10
10
0
10
10
% S
% Thr:
0
10
28
0
0
0
0
10
10
0
0
0
19
0
0
% T
% Val:
0
0
10
0
0
0
0
19
10
0
19
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% W
% Tyr:
0
0
0
0
0
0
10
37
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _