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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BRSK1 All Species: 11.52
Human Site: T539 Identified Species: 25.33
UniProt: Q8TDC3 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TDC3 NP_115806.1 794 86753 T539 P L H S P L H T P R A S P T G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_541413 801 87720 T546 P L H S P L H T P R A S P T G
Cat Felis silvestris
Mouse Mus musculus Q5RJI5 778 85136 T523 P L H S P L H T P R A S P T G
Rat Rattus norvegicus O08679 722 80853 S468 K K T T P T P S T N S V L S T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514667 306 34673 G54 R H Q G W D V G E F M Q K K A
Chicken Gallus gallus Q9IA88 798 88848 S521 N D S S V A L S S C L A G Q V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 R713 H P S N H L F R P A N Q S S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648814 861 95238 P567 D S N S V V N P N G S P M M N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A729 K L I N K T P A A G G T A A T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 V283 V V D P M K R V T I P E I R Q
Baker's Yeast Sacchar. cerevisiae P34244 1518 169574 D1060 P G S Y L S N D L D G I S D M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 98.1 N.A. 94.8 29.2 N.A. 32.1 28.3 N.A. 25.1 N.A. 48.5 N.A. 25.7 N.A.
Protein Similarity: 100 N.A. N.A. 98.2 N.A. 95.4 44.5 N.A. 33.3 43.9 N.A. 38.5 N.A. 62.5 N.A. 37.9 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 6.6 N.A. 0 6.6 N.A. 13.3 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 33.3 N.A. 0 20 N.A. 26.6 N.A. 33.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27 22.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41.9 34.2 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 10 10 10 28 10 10 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % C
% Asp: 10 10 10 0 0 10 0 10 0 10 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 0 0 0 10 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % F
% Gly: 0 10 0 10 0 0 0 10 0 19 19 0 10 0 28 % G
% His: 10 10 28 0 10 0 28 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 10 0 10 10 0 0 % I
% Lys: 19 10 0 0 10 10 0 0 0 0 0 0 10 10 0 % K
% Leu: 0 37 0 0 10 37 10 0 10 0 10 0 10 0 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 10 0 10 10 10 % M
% Asn: 10 0 10 19 0 0 19 0 10 10 10 0 0 0 10 % N
% Pro: 37 10 0 10 37 0 19 10 37 0 10 10 28 0 10 % P
% Gln: 0 0 10 0 0 0 0 0 0 0 0 19 0 10 10 % Q
% Arg: 10 0 0 0 0 0 10 10 0 28 0 0 0 10 0 % R
% Ser: 0 10 28 46 0 10 0 19 10 0 19 28 19 19 0 % S
% Thr: 0 0 10 10 0 19 0 28 19 0 0 10 0 28 19 % T
% Val: 10 10 0 0 19 10 10 10 0 0 0 10 0 0 10 % V
% Trp: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _