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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HELQ All Species: 7.58
Human Site: S217 Identified Species: 16.67
UniProt: Q8TDG4 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TDG4 NP_598375.2 1101 124175 S217 S N D L G D H S M K E R D W K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001104832 1101 124326 S217 S N D L G N C S M K E R D W K
Dog Lupus familis XP_544959 1072 121306 L207 H K I G N E E L P Q N S T E H
Cat Felis silvestris
Mouse Mus musculus Q2VPA6 1069 119080 D208 E Q P E P N N D F S N V R A A
Rat Rattus norvegicus NP_001014156 1065 118695 D207 Q P K S D F S D V G G S S E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517710 972 107104 I135 G S R R P L T I A A S G G R C
Chicken Gallus gallus XP_420565 1048 116823 R207 P D S G H K N R S T K S S K G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_691411 1010 112859 S173 A V N H A D L S V N K P H P K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648178 1051 117314 K210 Y V T C E E L K N Q S L L D P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001022911 923 102951 P86 P I Q Q K I G P P V L K R S S
Sea Urchin Strong. purpuratus XP_796097 1147 129034 T253 R M E K S S I T S V C V N T K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.9 83.1 N.A. 75.1 75.3 N.A. 56.6 61.5 N.A. 54.7 N.A. 36.9 N.A. 32.7 40.7
Protein Similarity: 100 N.A. 98.7 90.2 N.A. 84.4 84.9 N.A. 68 74.3 N.A. 71.1 N.A. 56.9 N.A. 51.4 59.7
P-Site Identity: 100 N.A. 86.6 0 N.A. 0 0 N.A. 0 0 N.A. 20 N.A. 0 N.A. 0 6.6
P-Site Similarity: 100 N.A. 93.3 13.3 N.A. 13.3 6.6 N.A. 6.6 20 N.A. 46.6 N.A. 13.3 N.A. 6.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 0 0 0 10 10 0 0 0 10 19 % A
% Cys: 0 0 0 10 0 0 10 0 0 0 10 0 0 0 10 % C
% Asp: 0 10 19 0 10 19 0 19 0 0 0 0 19 10 0 % D
% Glu: 10 0 10 10 10 19 10 0 0 0 19 0 0 19 0 % E
% Phe: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 0 % F
% Gly: 10 0 0 19 19 0 10 0 0 10 10 10 10 0 10 % G
% His: 10 0 0 10 10 0 10 0 0 0 0 0 10 0 10 % H
% Ile: 0 10 10 0 0 10 10 10 0 0 0 0 0 0 0 % I
% Lys: 0 10 10 10 10 10 0 10 0 19 19 10 0 10 37 % K
% Leu: 0 0 0 19 0 10 19 10 0 0 10 10 10 0 0 % L
% Met: 0 10 0 0 0 0 0 0 19 0 0 0 0 0 0 % M
% Asn: 0 19 10 0 10 19 19 0 10 10 19 0 10 0 0 % N
% Pro: 19 10 10 0 19 0 0 10 19 0 0 10 0 10 10 % P
% Gln: 10 10 10 10 0 0 0 0 0 19 0 0 0 0 0 % Q
% Arg: 10 0 10 10 0 0 0 10 0 0 0 19 19 10 0 % R
% Ser: 19 10 10 10 10 10 10 28 19 10 19 28 19 10 10 % S
% Thr: 0 0 10 0 0 0 10 10 0 10 0 0 10 10 0 % T
% Val: 0 19 0 0 0 0 0 0 19 19 0 19 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 19 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _