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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC2
All Species:
22.42
Human Site:
S406
Identified Species:
82.22
UniProt:
Q8TDI7
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TDI7
NP_542789.2
906
102582
S406
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Chimpanzee
Pan troglodytes
XP_001156297
903
102118
S403
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Rhesus Macaque
Macaca mulatta
XP_001110485
890
100607
F392
L
V
L
F
G
L
I
F
G
L
V
I
I
P
E
Dog
Lupus familis
XP_534369
893
101765
S393
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4P4
888
101116
S388
K
Y
V
S
I
T
T
S
F
K
E
S
I
V
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512038
976
111408
S475
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001041502
956
108121
S452
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
82.1
86.8
N.A.
82
N.A.
N.A.
67.7
N.A.
N.A.
N.A.
50.9
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
83.5
90.5
N.A.
87.9
N.A.
N.A.
77.3
N.A.
N.A.
N.A.
63.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
93.3
N.A.
N.A.
100
N.A.
N.A.
N.A.
100
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
N.A.
N.A.
100
N.A.
N.A.
N.A.
100
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
72
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
86
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
86
0
0
0
15
% E
% Phe:
0
0
0
15
0
0
0
15
86
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
15
0
0
0
15
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
86
0
15
0
0
0
0
15
100
0
0
% I
% Lys:
86
0
0
0
0
0
0
0
0
86
0
0
0
0
0
% K
% Leu:
15
0
15
0
0
15
0
0
0
15
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
86
0
0
0
86
0
0
0
86
0
0
0
% S
% Thr:
0
0
0
0
0
86
86
0
0
0
0
0
0
0
0
% T
% Val:
0
15
15
0
0
0
0
0
0
0
15
0
0
86
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
86
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _