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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC1
All Species:
11.21
Human Site:
T17
Identified Species:
24.67
UniProt:
Q8TDI8
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TDI8
NP_619636.2
760
87768
T17
V
E
E
K
E
D
E
T
E
E
S
S
S
E
E
Chimpanzee
Pan troglodytes
XP_528322
760
87690
T17
V
E
E
K
E
D
E
T
E
E
S
S
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001093188
807
93201
T46
V
E
E
K
E
D
E
T
E
E
S
S
S
E
E
Dog
Lupus familis
XP_541284
859
98517
N62
R
D
H
G
I
I
L
N
S
K
S
S
S
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4P5
757
87246
D40
P
K
R
K
R
T
R
D
V
I
N
E
D
D
P
Rat
Rattus norvegicus
Q496Z4
698
78193
R19
F
P
A
W
S
S
S
R
K
A
R
T
G
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512038
976
111408
K107
I
P
G
K
Q
N
L
K
A
E
S
S
L
N
N
Chicken
Gallus gallus
Q5YCC7
1138
128744
S41
Q
E
P
P
H
S
N
S
D
E
D
I
S
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695621
820
93823
R18
K
L
G
E
K
L
Q
R
K
E
Q
T
R
G
K
Tiger Blowfish
Takifugu rubipres
NP_001041502
956
108121
R64
H
R
K
A
K
R
T
R
D
E
D
E
E
E
D
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11069
1203
136041
V25
G
G
E
T
G
Q
S
V
K
S
L
A
D
V
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
92.4
85.2
N.A.
95.9
22.6
N.A.
49
28.2
N.A.
55.8
44.1
N.A.
N.A.
21.9
N.A.
Protein Similarity:
100
99.6
92.8
86.3
N.A.
97.6
43
N.A.
62.7
42.7
N.A.
72
57.6
N.A.
N.A.
36.9
N.A.
P-Site Identity:
100
100
100
33.3
N.A.
6.6
0
N.A.
26.6
33.3
N.A.
6.6
13.3
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
46.6
N.A.
26.6
13.3
N.A.
46.6
46.6
N.A.
46.6
40
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
10
10
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
28
0
10
19
0
19
0
19
10
10
% D
% Glu:
0
37
37
10
28
0
28
0
28
64
0
19
10
55
46
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
10
19
10
10
0
0
0
0
0
0
0
10
10
0
% G
% His:
10
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
10
10
0
0
0
10
0
10
0
0
0
% I
% Lys:
10
10
10
46
19
0
0
10
28
10
0
0
0
0
10
% K
% Leu:
0
10
0
0
0
10
19
0
0
0
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
10
10
0
0
10
0
0
10
10
% N
% Pro:
10
19
10
10
0
0
0
0
0
0
0
0
0
10
10
% P
% Gln:
10
0
0
0
10
10
10
0
0
0
10
0
0
0
0
% Q
% Arg:
10
10
10
0
10
10
10
28
0
0
10
0
10
0
0
% R
% Ser:
0
0
0
0
10
19
19
10
10
10
46
46
46
0
19
% S
% Thr:
0
0
0
10
0
10
10
28
0
0
0
19
0
0
0
% T
% Val:
28
0
0
0
0
0
0
10
10
0
0
0
0
10
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _