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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRRC8C
All Species:
25.76
Human Site:
Y108
Identified Species:
56.67
UniProt:
Q8TDW0
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TDW0
NP_115646.2
803
92392
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Chimpanzee
Pan troglodytes
XP_001160980
841
97525
Y137
Y
D
L
D
R
H
Q
Y
N
Y
V
D
A
V
C
Rhesus Macaque
Macaca mulatta
XP_001087650
803
92361
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Dog
Lupus familis
XP_547289
803
92303
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8R502
803
92353
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Rat
Rattus norvegicus
Q498T9
803
92444
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520382
756
86845
E109
P
G
S
S
S
K
I
E
H
F
I
S
I
L
G
Chicken
Gallus gallus
Q5F4C4
529
59144
Frog
Xenopus laevis
Q6NU09
806
92226
Y113
N
N
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Zebra Danio
Brachydanio rerio
XP_001919381
792
91555
E106
Y
I
N
Q
M
C
Y
E
K
A
L
H
W
Y
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22875
559
62465
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
55.4
99.8
99.1
N.A.
97.5
98.1
N.A.
87.9
20.2
63.7
77.9
N.A.
N.A.
N.A.
21.1
N.A.
Protein Similarity:
100
72.5
99.8
99.6
N.A.
98.6
99
N.A.
90.9
35.7
79.6
88
N.A.
N.A.
N.A.
37.9
N.A.
P-Site Identity:
100
40
100
100
N.A.
100
100
N.A.
13.3
0
86.6
0
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
33.3
0
93.3
20
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
10
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
64
% C
% Asp:
0
55
0
64
0
0
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
64
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
10
0
0
10
0
0
10
0
0
0
% H
% Ile:
0
10
0
0
0
0
10
0
0
0
64
0
10
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% K
% Leu:
0
0
64
0
55
0
0
0
0
0
10
0
0
10
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
55
0
% M
% Asn:
10
10
10
0
0
0
0
0
10
0
0
55
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
55
64
0
0
0
0
0
55
0
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
10
10
10
0
0
0
55
0
0
10
0
0
0
% S
% Thr:
46
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
19
0
0
0
0
0
10
64
0
10
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _