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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NSUN6 All Species: 18.79
Human Site: S427 Identified Species: 34.44
UniProt: Q8TEA1 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TEA1 NP_872349.1 469 51770 S427 Q L Q R F D P S A V P L P D T
Chimpanzee Pan troglodytes XP_507683 469 51748 S427 Q L Q R F D P S A V P L P D T
Rhesus Macaque Macaca mulatta XP_001094308 311 34278 V272 M D K I F S K V E K I K Q N A
Dog Lupus familis XP_544240 469 51842 S427 Q L Q R F D P S V V P S W D T
Cat Felis silvestris
Mouse Mus musculus Q7TS68 476 52260 S427 Q L Q R F D P S V V P L Q N M
Rat Rattus norvegicus NP_001100837 476 52290 C427 Q L Q R F D P C V V P L E S M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509484 466 50374 A427 R L Q R F D P A A V P A E G P
Chicken Gallus gallus XP_425980 469 51903 S427 L L Q R F D P S A G T L Q G T
Frog Xenopus laevis NP_001090297 467 51218 S428 L L Q R F D P S R V E F C S V
Zebra Danio Brachydanio rerio XP_001919347 417 45924 R375 G L S C E Q R R L L Q R F R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730761 439 47926 T395 E L R L T D A T P R W G G P G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001145845 585 64025 K544 G S C E L F N K T Y T E E W L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40991 618 69794 N557 G P S S F D D N Q A S A K E K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 64.3 88.2 N.A. 80 78.9 N.A. 68.2 73.7 68.8 48.8 N.A. 39.8 N.A. N.A. N.A.
Protein Similarity: 100 99.3 66 93.3 N.A. 87.8 88.4 N.A. 80.1 86.1 81.8 66 N.A. 56.5 N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 80 N.A. 73.3 66.6 N.A. 60 66.6 53.3 6.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 20 80 N.A. 80 66.6 N.A. 73.3 66.6 53.3 13.3 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. 28.8 N.A. N.A. 20.8 N.A.
Protein Similarity: N.A. 45.1 N.A. N.A. 36.4 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. 0 N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 8 31 8 0 16 0 0 8 % A
% Cys: 0 0 8 8 0 0 0 8 0 0 0 0 8 0 0 % C
% Asp: 0 8 0 0 0 77 8 0 0 0 0 0 0 24 0 % D
% Glu: 8 0 0 8 8 0 0 0 8 0 8 8 24 8 0 % E
% Phe: 0 0 0 0 77 8 0 0 0 0 0 8 8 0 0 % F
% Gly: 24 0 0 0 0 0 0 0 0 8 0 8 8 16 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 0 0 8 0 0 0 8 8 0 8 0 8 8 0 8 % K
% Leu: 16 77 0 8 8 0 0 0 8 8 0 39 0 0 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % M
% Asn: 0 0 0 0 0 0 8 8 0 0 0 0 0 16 0 % N
% Pro: 0 8 0 0 0 0 62 0 8 0 47 0 16 8 16 % P
% Gln: 39 0 62 0 0 8 0 0 8 0 8 0 24 0 0 % Q
% Arg: 8 0 8 62 0 0 8 8 8 8 0 8 0 8 0 % R
% Ser: 0 8 16 8 0 8 0 47 0 0 8 8 0 16 0 % S
% Thr: 0 0 0 0 8 0 0 8 8 0 16 0 0 0 31 % T
% Val: 0 0 0 0 0 0 0 8 24 54 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _