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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBCK
All Species:
24.24
Human Site:
S746
Identified Species:
44.44
UniProt:
Q8TEA7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TEA7
NP_001156907.1
893
100680
S746
D
P
P
K
T
D
L
S
R
E
S
I
P
L
N
Chimpanzee
Pan troglodytes
XP_526648
893
100716
S746
D
P
P
K
T
D
L
S
R
E
S
I
P
L
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545015
893
100744
S746
D
P
P
K
T
D
L
S
R
E
S
I
P
L
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM85
762
86353
A623
G
F
I
P
D
L
Y
A
I
P
W
F
L
T
M
Rat
Rattus norvegicus
NP_001127985
860
96794
S713
D
P
P
K
T
D
L
S
R
E
S
I
P
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510722
898
101284
S751
D
A
P
L
T
D
L
S
R
E
S
I
D
L
D
Chicken
Gallus gallus
Q5F361
893
100434
S746
E
A
P
R
G
D
L
S
R
D
S
I
K
L
D
Frog
Xenopus laevis
NP_001087131
893
100210
G746
E
S
P
K
T
D
L
G
R
E
P
I
N
I
D
Zebra Danio
Brachydanio rerio
NP_001074106
893
100952
S746
E
L
T
K
T
D
L
S
R
E
P
L
K
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572197
819
93251
L680
H
R
Q
H
A
L
R
L
Q
P
P
Q
A
L
D
Honey Bee
Apis mellifera
XP_393033
792
90269
K653
P
P
S
I
T
Y
R
K
H
Q
F
N
Q
P
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001199652
877
98431
K737
K
Y
A
H
P
P
K
K
V
D
R
I
T
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32491
506
56739
A367
D
F
G
V
S
G
E
A
V
N
S
L
A
M
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
96.7
N.A.
81
90.5
N.A.
90.3
87.1
81.5
76.7
N.A.
43.6
47.5
N.A.
55.2
Protein Similarity:
100
99.7
N.A.
98.8
N.A.
83.5
94.2
N.A.
94.5
92.8
90
87.6
N.A.
58.5
62.7
N.A.
70.8
P-Site Identity:
100
100
N.A.
100
N.A.
0
93.3
N.A.
73.3
53.3
53.3
53.3
N.A.
6.6
13.3
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
6.6
100
N.A.
80
80
73.3
73.3
N.A.
20
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
0
8
0
0
16
0
0
0
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
0
8
62
0
0
0
16
0
0
8
0
31
% D
% Glu:
24
0
0
0
0
0
8
0
0
54
0
0
0
0
0
% E
% Phe:
0
16
0
0
0
0
0
0
0
0
8
8
0
0
0
% F
% Gly:
8
0
8
0
8
8
0
8
0
0
0
0
0
0
0
% G
% His:
8
0
0
16
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
0
0
0
0
8
0
0
62
0
8
0
% I
% Lys:
8
0
0
47
0
0
8
16
0
0
0
0
16
0
8
% K
% Leu:
0
8
0
8
0
16
62
8
0
0
0
16
8
62
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
8
8
0
24
% N
% Pro:
8
39
54
8
8
8
0
0
0
16
24
0
31
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
8
8
0
8
8
0
0
% Q
% Arg:
0
8
0
8
0
0
16
0
62
0
8
0
0
0
0
% R
% Ser:
0
8
8
0
8
0
0
54
0
0
54
0
0
0
16
% S
% Thr:
0
0
8
0
62
0
0
0
0
0
0
0
8
8
16
% T
% Val:
0
0
0
8
0
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _