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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DOT1L
All Species:
11.52
Human Site:
S650
Identified Species:
36.19
UniProt:
Q8TEK3
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TEK3
NP_115871.1
1739
184853
S650
S
I
V
E
L
E
K
S
Q
R
Q
Q
E
L
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097213
1737
184135
S655
S
I
V
E
L
E
K
S
Q
R
Q
Q
E
L
L
Dog
Lupus familis
XP_542191
1790
190684
S733
S
I
V
E
L
E
K
S
Q
R
Q
Q
E
L
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_955354
1540
165894
Q495
S
F
R
I
Q
Y
L
Q
F
L
A
Y
T
K
T
Rat
Rattus norvegicus
NP_001102203
1549
166804
Q504
S
F
K
I
Q
Y
L
Q
F
L
A
Y
T
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919781
1377
151040
P332
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8INR6
1848
201265
S667
I
L
L
D
V
F
R
S
Q
Y
T
S
M
I
E
Honey Bee
Apis mellifera
XP_394544
1385
154106
L340
F
R
I
T
D
R
N
L
S
D
I
G
T
I
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
95.1
81.6
N.A.
74.6
74.4
N.A.
N.A.
N.A.
N.A.
48.3
N.A.
23.4
29.2
N.A.
N.A.
Protein Similarity:
100
N.A.
96.3
85.7
N.A.
79
78.9
N.A.
N.A.
N.A.
N.A.
57.5
N.A.
38.1
42.8
N.A.
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
13.3
0
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
40
N.A.
53.3
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
25
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
13
0
0
0
0
13
0
0
0
0
0
% D
% Glu:
0
0
0
38
0
38
0
0
0
0
0
13
50
0
25
% E
% Phe:
13
38
0
0
0
13
0
0
25
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
13
38
13
25
0
0
0
0
0
0
13
0
0
25
0
% I
% Lys:
0
0
13
0
0
13
38
0
13
0
0
0
0
25
0
% K
% Leu:
0
13
13
0
50
0
25
13
0
38
0
0
0
38
38
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
13
% M
% Asn:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
25
0
0
25
50
0
38
38
0
13
0
% Q
% Arg:
0
13
13
0
0
13
13
0
0
38
13
0
0
0
0
% R
% Ser:
63
0
13
13
0
0
0
50
13
0
0
13
0
0
0
% S
% Thr:
0
0
0
13
0
0
0
0
0
0
13
0
38
0
25
% T
% Val:
0
0
38
0
13
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
13
0
0
0
0
25
0
0
0
13
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _