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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOT1L All Species: 8.18
Human Site: S786 Identified Species: 25.71
UniProt: Q8TEK3 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TEK3 NP_115871.1 1739 184853 S786 I V L R R H L S Q D H T V P G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001097213 1737 184135 S791 I V L R R H L S Q D H T V P G
Dog Lupus familis XP_542191 1790 190684 S869 L V L R R H L S Q D H A T S G
Cat Felis silvestris
Mouse Mus musculus NP_955354 1540 165894 I628 K Q A L R S Q I S E K Q R H C
Rat Rattus norvegicus NP_001102203 1549 166804 I637 K Q A L R S Q I S E K Q R H C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919781 1377 151040 Q465 Y Q L P P K V Q H Y T S S Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8INR6 1848 201265 E802 V K L E V P P E L S E T T A Q
Honey Bee Apis mellifera XP_394544 1385 154106 P473 K S N G I T R P P A R G R Q R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 95.1 81.6 N.A. 74.6 74.4 N.A. N.A. N.A. N.A. 48.3 N.A. 23.4 29.2 N.A. N.A.
Protein Similarity: 100 N.A. 96.3 85.7 N.A. 79 78.9 N.A. N.A. N.A. N.A. 57.5 N.A. 38.1 42.8 N.A. N.A.
P-Site Identity: 100 N.A. 100 73.3 N.A. 6.6 6.6 N.A. N.A. N.A. N.A. 6.6 N.A. 13.3 0 N.A. N.A.
P-Site Similarity: 100 N.A. 100 80 N.A. 13.3 13.3 N.A. N.A. N.A. N.A. 20 N.A. 20 0 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 25 0 0 0 0 0 0 13 0 13 0 13 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % C
% Asp: 0 0 0 0 0 0 0 0 0 38 0 0 0 0 0 % D
% Glu: 0 0 0 13 0 0 0 13 0 25 13 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 13 0 0 0 0 0 0 0 13 0 0 38 % G
% His: 0 0 0 0 0 38 0 0 13 0 38 0 0 25 0 % H
% Ile: 25 0 0 0 13 0 0 25 0 0 0 0 0 0 0 % I
% Lys: 38 13 0 0 0 13 0 0 0 0 25 0 0 0 0 % K
% Leu: 13 0 63 25 0 0 38 0 13 0 0 0 0 0 13 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 13 13 13 13 13 13 0 0 0 0 25 0 % P
% Gln: 0 38 0 0 0 0 25 13 38 0 0 25 0 25 13 % Q
% Arg: 0 0 0 38 63 0 13 0 0 0 13 0 38 0 13 % R
% Ser: 0 13 0 0 0 25 0 38 25 13 0 13 13 13 0 % S
% Thr: 0 0 0 0 0 13 0 0 0 0 13 38 25 0 0 % T
% Val: 13 38 0 0 13 0 13 0 0 0 0 0 25 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 13 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _