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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
20.61
Human Site:
S134
Identified Species:
37.78
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S134
L
P
R
E
R
G
E
S
M
E
K
W
Q
T
R
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S134
L
P
R
E
R
G
E
S
M
E
K
W
Q
T
R
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S134
L
P
R
E
R
G
E
S
M
E
K
W
Q
T
R
Dog
Lupus familis
XP_535520
885
102054
R45
C
P
Q
P
A
A
C
R
N
D
G
K
L
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
A134
L
P
R
E
K
G
E
A
M
E
K
W
Q
T
R
Rat
Rattus norvegicus
Q5U2P0
1054
120741
A134
L
P
R
E
K
G
E
A
M
E
K
W
Q
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
S258
V
P
R
E
Q
G
E
S
M
E
K
W
Q
T
R
Chicken
Gallus gallus
XP_417016
963
109342
K119
D
V
I
G
N
P
E
K
H
F
Y
S
F
T
N
Frog
Xenopus laevis
Q6GN11
1040
119148
S130
L
P
R
E
M
G
E
S
A
L
A
W
Q
T
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S131
C
P
R
E
K
G
E
S
Q
D
K
W
H
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
K117
K
A
V
P
A
Y
K
K
M
N
S
L
C
Y
E
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
C47
S
C
S
M
S
E
R
C
V
G
R
N
V
S
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
V117
D
V
I
V
P
Q
I
V
L
D
E
V
R
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
100
6.6
N.A.
86.6
86.6
N.A.
86.6
13.3
73.3
66.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
100
13.3
73.3
80
N.A.
N.A.
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
16
8
0
16
8
0
8
0
0
0
0
% A
% Cys:
16
8
0
0
0
0
8
8
0
0
0
0
8
0
0
% C
% Asp:
16
0
0
0
0
0
0
0
0
24
0
0
0
0
0
% D
% Glu:
0
0
0
62
0
8
70
0
0
47
8
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
0
0
0
8
0
62
0
0
0
8
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
8
% H
% Ile:
0
0
16
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
24
0
8
16
0
0
54
8
0
0
8
% K
% Leu:
47
0
0
0
0
0
0
0
8
8
0
8
8
8
0
% L
% Met:
0
0
0
8
8
0
0
0
54
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
8
8
0
8
0
8
8
% N
% Pro:
0
70
0
16
8
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
8
8
0
0
8
0
0
0
54
0
0
% Q
% Arg:
0
0
62
0
24
0
8
8
0
0
8
0
8
0
62
% R
% Ser:
8
0
8
0
8
0
0
47
0
0
8
8
0
8
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
70
0
% T
% Val:
8
16
8
8
0
0
0
8
8
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
62
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _