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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
28.48
Human Site:
S217
Identified Species:
52.22
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S217
R
R
E
R
E
N
E
S
Q
E
S
H
G
K
E
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S217
R
R
E
R
E
N
E
S
Q
E
S
H
G
K
E
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S217
R
R
E
R
E
N
E
S
Q
E
S
H
G
K
E
Dog
Lupus familis
XP_535520
885
102054
Y126
N
E
F
Q
Q
Y
C
Y
L
P
R
E
R
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
S217
R
R
E
R
E
T
E
S
Q
E
T
H
G
K
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S217
R
R
E
R
E
S
E
S
Q
E
T
H
G
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
S341
R
H
E
R
E
S
E
S
L
E
N
H
G
K
E
Chicken
Gallus gallus
XP_417016
963
109342
Y200
T
A
Y
T
C
E
E
Y
I
K
S
L
I
D
N
Frog
Xenopus laevis
Q6GN11
1040
119148
S213
H
L
E
R
K
L
E
S
R
E
S
N
G
K
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G214
L
Q
E
R
E
N
D
G
A
E
K
V
Y
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
Y198
N
H
Y
Q
H
V
M
Y
L
K
E
Y
I
Q
N
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
E128
F
S
P
R
Q
H
G
E
S
E
E
E
W
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D198
N
V
V
L
V
T
N
D
R
L
N
R
E
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
100
6.6
N.A.
86.6
86.6
N.A.
73.3
13.3
60
40
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
100
100
20
N.A.
93.3
100
N.A.
86.6
20
80
53.3
N.A.
N.A.
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
8
0
0
0
0
8
8
% A
% Cys:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
8
0
0
0
0
0
8
0
% D
% Glu:
0
8
62
0
54
8
62
8
0
70
16
16
8
0
70
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
8
0
0
0
0
54
8
0
% G
% His:
8
16
0
0
8
8
0
0
0
0
0
47
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
16
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
16
8
0
0
54
0
% K
% Leu:
8
8
0
8
0
8
0
0
24
8
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
24
0
0
0
0
31
8
0
0
0
16
8
0
0
16
% N
% Pro:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
8
0
16
16
0
0
0
39
0
0
0
0
16
0
% Q
% Arg:
47
39
0
70
0
0
0
0
16
0
8
8
8
0
0
% R
% Ser:
0
8
0
0
0
16
0
54
8
0
39
0
0
0
0
% S
% Thr:
8
0
0
8
0
16
0
0
0
0
16
0
0
8
8
% T
% Val:
0
8
8
0
8
8
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
16
0
0
8
0
24
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _