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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3L All Species: 26.06
Human Site: S476 Identified Species: 47.78
UniProt: Q8TF46 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TF46 NP_001137160.1 1054 120787 S476 R K S H L V F S I D P K G C E
Chimpanzee Pan troglodytes XP_001174669 1054 120822 S476 R K S H L V F S I D P K G C E
Rhesus Macaque Macaca mulatta XP_001110092 1054 120876 S476 R K S H L V F S I D P K G C E
Dog Lupus familis XP_535520 885 102054 R365 T T Y Y L A D R R Y D M L P S
Cat Felis silvestris
Mouse Mus musculus Q8C0S1 1053 120265 S476 R T T H L V F S I D P K G C E
Rat Rattus norvegicus Q5U2P0 1054 120741 S476 R S T H L V F S I D P K G C E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511394 1174 132085 S599 R K T H L V F S I D P K D C E
Chicken Gallus gallus XP_417016 963 109342 E439 E T E V L L L E H D V P H Q P
Frog Xenopus laevis Q6GN11 1040 119148 I471 E T H L V F S I D P K G C E D
Zebra Danio Brachydanio rerio A2RV18 1057 120333 S470 R D S H L V F S I D P K G C E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17632 961 108768 N439 M G S R E T E N E V L L L E H
Sea Urchin Strong. purpuratus XP_001200561 887 101086 R367 L V I P W D Y R I P K I R V S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 R440 K V R I R T R R A A E L L D K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98 77.9 N.A. 91.5 91.4 N.A. 65.2 33.8 68.6 64 N.A. N.A. N.A. 31.5 48.4
Protein Similarity: 100 99.8 98.9 81.3 N.A. 96.3 96.5 N.A. 74.8 53 81.6 79 N.A. N.A. N.A. 50.7 64.7
P-Site Identity: 100 100 100 6.6 N.A. 86.6 86.6 N.A. 86.6 13.3 0 93.3 N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: 100 100 100 13.3 N.A. 93.3 93.3 N.A. 93.3 20 13.3 93.3 N.A. N.A. N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 0 8 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 54 0 % C
% Asp: 0 8 0 0 0 8 8 0 8 62 8 0 8 8 8 % D
% Glu: 16 0 8 0 8 0 8 8 8 0 8 0 0 16 54 % E
% Phe: 0 0 0 0 0 8 54 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 0 0 0 0 0 8 47 0 0 % G
% His: 0 0 8 54 0 0 0 0 8 0 0 0 8 0 8 % H
% Ile: 0 0 8 8 0 0 0 8 62 0 0 8 0 0 0 % I
% Lys: 8 31 0 0 0 0 0 0 0 0 16 54 0 0 8 % K
% Leu: 8 0 0 8 70 8 8 0 0 0 8 16 24 0 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 8 0 0 0 0 0 16 54 8 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 54 0 8 8 8 0 8 24 8 0 0 0 8 0 0 % R
% Ser: 0 8 39 0 0 0 8 54 0 0 0 0 0 0 16 % S
% Thr: 8 31 24 0 0 16 0 0 0 0 0 0 0 0 0 % T
% Val: 0 16 0 8 8 54 0 0 0 8 8 0 0 8 0 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 8 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _