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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
26.67
Human Site:
S490
Identified Species:
48.89
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S490
E
D
V
D
D
T
L
S
V
R
T
L
N
N
G
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S490
E
D
V
D
D
T
L
S
V
R
T
L
N
N
G
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S490
E
D
V
D
D
T
L
S
I
R
T
L
N
N
G
Dog
Lupus familis
XP_535520
885
102054
C379
S
I
L
S
A
D
L
C
S
L
L
G
G
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
S490
E
D
V
D
D
T
L
S
V
R
T
L
N
N
G
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S490
E
D
V
D
D
A
L
S
V
R
T
L
N
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
S613
E
D
V
D
D
A
L
S
V
R
T
L
E
N
G
Chicken
Gallus gallus
XP_417016
963
109342
S453
P
F
S
Q
N
V
L
S
F
L
P
K
M
P
W
Frog
Xenopus laevis
Q6GN11
1040
119148
I485
D
V
D
D
A
L
S
I
R
V
L
P
S
G
D
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S484
E
D
V
D
D
T
L
S
V
R
T
L
P
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
F453
H
D
I
P
H
A
P
F
S
E
S
V
L
D
C
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
L381
S
T
R
Q
A
D
A
L
N
D
Q
R
I
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D454
K
R
I
V
I
S
I
D
S
W
P
T
T
H
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
93.3
6.6
N.A.
100
93.3
N.A.
86.6
13.3
6.6
86.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
13.3
N.A.
100
93.3
N.A.
86.6
20
20
86.6
N.A.
N.A.
N.A.
33.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
24
24
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% C
% Asp:
8
62
8
62
54
16
0
8
0
8
0
0
0
8
16
% D
% Glu:
54
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
8
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
8
16
54
% G
% His:
8
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
8
16
0
8
0
8
8
8
0
0
0
8
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% K
% Leu:
0
0
8
0
0
8
70
8
0
16
16
54
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
8
0
0
0
39
47
0
% N
% Pro:
8
0
0
8
0
0
8
0
0
0
16
8
8
8
0
% P
% Gln:
0
0
0
16
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
8
8
0
0
0
0
0
8
54
0
8
0
0
0
% R
% Ser:
16
0
8
8
0
8
8
62
24
0
8
0
8
0
0
% S
% Thr:
0
8
0
0
0
39
0
0
0
0
54
8
8
0
0
% T
% Val:
0
8
54
8
0
8
0
0
47
8
0
8
0
16
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _