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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
22.73
Human Site:
S541
Identified Species:
41.67
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S541
R
R
Y
D
M
L
P
S
V
L
S
A
D
L
C
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S541
R
R
Y
D
M
L
P
S
V
L
S
A
D
L
C
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S541
R
R
Y
D
M
L
P
S
V
L
S
A
D
L
C
Dog
Lupus familis
XP_535520
885
102054
D429
E
A
A
Q
E
L
L
D
G
N
V
T
V
V
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
S541
R
R
Y
D
M
L
P
S
I
L
S
A
D
L
C
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S541
R
R
Y
D
M
L
P
S
I
L
S
A
D
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
S664
R
R
Y
D
M
L
P
S
I
L
S
S
N
L
C
Chicken
Gallus gallus
XP_417016
963
109342
E504
E
I
E
N
G
N
L
E
V
G
V
H
I
A
D
Frog
Xenopus laevis
Q6GN11
1040
119148
L535
R
R
N
D
M
L
P
L
I
L
S
A
D
L
C
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A536
R
R
Y
D
M
L
P
A
V
L
S
A
D
L
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
H503
T
D
I
D
D
A
L
H
C
K
Q
I
G
E
D
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
P431
E
N
S
L
P
V
G
P
F
S
E
G
Q
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
P504
K
K
V
L
E
C
L
P
A
E
G
H
D
W
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
80
6.6
80
93.3
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
100
13.3
86.6
100
N.A.
N.A.
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
0
8
8
0
0
54
0
8
0
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
62
% C
% Asp:
0
8
0
70
8
0
0
8
0
0
0
0
62
0
16
% D
% Glu:
24
0
8
0
16
0
0
8
0
8
8
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
8
0
8
8
8
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
16
0
0
0
% H
% Ile:
0
8
8
0
0
0
0
0
31
0
0
8
8
8
0
% I
% Lys:
8
8
0
0
0
0
0
0
0
8
0
0
0
0
16
% K
% Leu:
0
0
0
16
0
70
31
8
0
62
0
0
0
62
0
% L
% Met:
0
0
0
0
62
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
0
8
0
0
0
8
0
0
8
0
0
% N
% Pro:
0
0
0
0
8
0
62
16
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% Q
% Arg:
62
62
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
47
0
8
62
8
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
0
8
0
0
8
0
0
39
0
16
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
54
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _