KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
14.85
Human Site:
S617
Identified Species:
27.22
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S617
F
K
D
L
D
E
K
S
R
Q
A
K
L
E
E
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S617
F
K
D
L
D
E
K
S
R
Q
A
K
L
E
E
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S617
F
K
D
L
D
E
K
S
K
Q
A
K
L
E
E
Dog
Lupus familis
XP_535520
885
102054
P505
H
D
L
I
P
K
Q
P
L
E
V
H
E
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
S617
L
K
A
L
D
K
Q
S
Q
Q
A
K
L
E
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
N617
F
K
T
L
E
E
Q
N
R
Q
A
K
L
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
R740
R
G
L
D
E
E
M
R
Q
R
R
L
E
E
L
Chicken
Gallus gallus
XP_417016
963
109342
F580
A
E
I
L
K
T
R
F
T
K
S
I
I
N
S
Frog
Xenopus laevis
Q6GN11
1040
119148
P611
L
H
P
L
K
Q
D
P
A
R
L
Q
Q
L
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Q612
L
K
G
S
Q
R
D
Q
K
M
S
E
L
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
T579
F
S
C
I
W
T
M
T
S
S
A
D
I
Q
S
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
K507
A
D
V
S
Y
F
V
K
E
G
S
L
T
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
G580
V
T
H
F
V
K
P
G
T
A
L
D
A
E
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
93.3
0
N.A.
66.6
73.3
N.A.
13.3
6.6
6.6
13.3
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
100
100
100
26.6
N.A.
86.6
93.3
N.A.
33.3
40
26.6
40
N.A.
N.A.
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
8
0
0
0
0
0
8
8
47
0
8
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
24
8
31
0
16
0
0
0
0
16
0
8
0
% D
% Glu:
0
8
0
0
16
39
0
0
8
8
0
8
16
54
39
% E
% Phe:
39
0
0
8
0
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
8
8
0
0
0
0
8
0
8
0
0
0
0
8
% G
% His:
8
8
8
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
8
16
0
0
0
0
0
0
0
8
16
0
0
% I
% Lys:
0
47
0
0
16
24
24
8
16
8
0
39
0
0
0
% K
% Leu:
24
0
16
54
0
0
0
0
8
0
16
16
47
16
24
% L
% Met:
0
0
0
0
0
0
16
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% N
% Pro:
0
0
8
0
8
0
8
16
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
24
8
16
39
0
8
8
8
8
% Q
% Arg:
8
0
0
0
0
8
8
8
24
16
8
0
0
0
0
% R
% Ser:
0
8
0
16
0
0
0
31
8
8
24
0
0
0
16
% S
% Thr:
0
8
8
0
0
16
0
8
16
0
0
0
8
8
0
% T
% Val:
8
0
8
0
8
0
8
0
0
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _