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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
22.12
Human Site:
S912
Identified Species:
40.56
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
S912
N
K
D
G
L
V
I
S
C
G
P
D
S
C
S
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
S912
N
K
D
G
L
V
I
S
C
G
P
D
S
C
S
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
S912
N
K
D
G
L
V
I
S
S
G
P
D
S
R
S
Dog
Lupus familis
XP_535520
885
102054
S748
V
I
S
C
G
S
D
S
R
S
E
W
K
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
S912
N
K
D
S
L
V
I
S
C
G
P
E
G
S
S
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S912
N
K
D
G
L
V
I
S
C
G
P
E
G
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
S1032
N
K
E
G
L
V
V
S
C
R
P
D
G
S
C
Chicken
Gallus gallus
XP_417016
963
109342
M826
N
L
N
Y
R
H
K
M
A
Q
Y
A
Q
R
A
Frog
Xenopus laevis
Q6GN11
1040
119148
A900
N
T
D
G
L
V
L
A
C
E
E
D
G
Q
C
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S904
D
R
E
G
Q
V
I
S
V
D
G
D
G
K
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
R823
S
G
L
L
N
Q
A
R
C
T
K
I
C
T
N
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
F750
I
D
R
R
D
P
V
F
N
K
I
L
R
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
R847
T
H
F
T
S
P
I
R
R
Y
C
D
V
V
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
86.6
6.6
N.A.
73.3
80
N.A.
60
6.6
46.6
33.3
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
86.6
6.6
N.A.
80
86.6
N.A.
73.3
20
60
53.3
N.A.
N.A.
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
8
8
0
0
8
0
0
16
% A
% Cys:
0
0
0
8
0
0
0
0
54
0
8
0
8
16
24
% C
% Asp:
8
8
47
0
8
0
8
0
0
8
0
54
0
0
0
% D
% Glu:
0
0
16
0
0
0
0
0
0
8
16
16
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
54
8
0
0
0
0
39
8
0
39
0
8
% G
% His:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
54
0
0
0
8
8
0
0
0
% I
% Lys:
0
47
0
0
0
0
8
0
0
8
8
0
8
8
0
% K
% Leu:
0
8
8
8
54
0
8
0
0
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
62
0
8
0
8
0
0
0
8
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
16
0
0
0
0
47
0
0
8
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
8
0
0
8
8
0
% Q
% Arg:
0
8
8
8
8
0
0
16
16
8
0
0
8
16
0
% R
% Ser:
8
0
8
8
8
8
0
62
8
8
0
0
24
31
39
% S
% Thr:
8
8
0
8
0
0
0
0
0
8
0
0
0
8
0
% T
% Val:
8
0
0
0
0
62
16
0
8
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _